Glutaminyl Cyclase Inhibitor 3

• 常用名: Glutaminyl Cyclase Inhibitor 3
• 英文名: Glutaminyl Cyclase Inhibitor 3
• CAS号: 2092921-50-9
• 分子量: 468.61
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₂N₆O₂S
• 熔点: N/A
• 闪点: N/A

Glutaminyl Cyclase Inhibitor 3用途

Glutaminyl Cyclase Inhibitor 3 (compound 212 ) 是一种具有抗阿尔兹海默症作用的化合物,是有效的人谷氨酰胺酰环化酶 (GC) 的抑制剂,其 IC50 值为 4.5 nM。Glutaminyl Cyclase-IN-1 (compound 212) 可显著降低大脑Aβ的浓度,并恢复认知功能。

Glutaminyl Cyclase Inhibitor 3名称

• 英文名: Glutaminyl Cyclase Inhibitor 3

Glutaminyl Cyclase Inhibitor 3生物活性

• 描述: Glutaminyl Cyclase Inhibitor 3 (compound 212 ) 是一种具有抗阿尔兹海默症作用的化合物,是有效的人谷氨酰胺酰环化酶 (GC) 的抑制剂,其 IC50 值为 4.5 nM。Glutaminyl Cyclase-IN-1 (compound 212) 可显著降低大脑Aβ的浓度,并恢复认知功能。
• 相关类别:
  研究领域 >> 神经疾病
• 靶点实验:

  IC50: 4.5 nM (hGC)[1].

• 参考文献:

  [1]. Hoang VH, et al. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60(6):2573-2590.

Glutaminyl Cyclase Inhibitor 3物理化学性质

• 分子式: C₂₄H₃₂N₆O₂S
• 分子量: 468.61
• InChIKey: MXAZSKBTKUGBLI-UHFFFAOYSA-N
• SMILES: COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(N)c1
• 储存条件: 2-8°C，密封，干燥

Glutaminyl Cyclase Inhibitor 3靶点实验

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实验名称：Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to L... 来源：ChEMBL 靶标：Glutaminyl-peptide cyclotransferase External Id：CHEMBL4376103

实验名称：Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as su... 来源：ChEMBL 靶标：Glutaminyl-peptide cyclotransferase External Id：CHEMBL5035499

实验名称：Cytotoxicity against mouse HT22 cells assessed as cell viability at 10 uM after 18 hr... 来源：ChEMBL 靶标：HT-22 External Id：CHEMBL4009739

实验名称：Antialzheimer activity in human amyloid beta (3 to 40) induced acute ICR mouse Alzhei... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4009740

实验名称：Ratio of IC50 for iso glutaminyl cyclase (unknown origin) to IC50 for human glutaminy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4009738

实验名称：Permeability, logPe of the compound after 4 hrs by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL4009734

实验名称：Toxicity in APP/PS1 transgenic Alzheimer's disease mouse model administered via icv f... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4009747

实验名称：Cognition enhancement activity in 5XFAD Alzheimer's disease mouse model assessed as r... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4009745

实验名称：Cognition enhancement activity in 5XFAD Alzheimer's disease mouse model assessed as i... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4009746

实验名称：In vivo inhibition of glutaminyl cyclase in APP/PS1 transgenic Alzheimer's disease mo... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4009743

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