N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((5-(4-fluorophenyl)-1H-indazol-3-yl)amino)-4-methoxyphenyl)acrylamide

• 常用名: N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((5-(4-fluorophenyl)-1H-indazol-3-yl)amino)-4-methoxyphenyl)acrylamide
• 英文名: N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((5-(4-fluorophenyl)-1H-indazol-3-yl)amino)-4-methoxyphenyl)acrylamide
• CAS号: 2093395-24-3
• 分子量: 502.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₃₁FN₆O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((5-(4-fluorophenyl)-1H-indazol-3-yl)amino)-4-methoxyphenyl)acrylamide

物理化学性质

• 分子式: C₂₈H₃₁FN₆O₂
• 分子量: 502.6
• InChIKey: IOFPXKOUVACVHI-UHFFFAOYSA-N
• SMILES: C=CC(=O)Nc1cc(Nc2n[nH]c3ccc(-c4ccc(F)cc4)cc23)c(OC)cc1N(C)CCN(C)C

靶点实验

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实验名称：Ratio of EC50 for wild-type EGFR in human A431 cells to EC50 for EGFR L858R/T790M dou... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4009539

实验名称：Ratio of EC50 for wild-type EGFR in human A431 cells to EC50 for EGFR delE746_A750 mu... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4009504

实验名称：Stability in mouse plasma assessed as compound remaining at 5 uM after 1 hr by LCMS a... 来源：ChEMBL 靶标：Plasma External Id：CHEMBL4009532

实验名称：Stability in mouse liver microsomes at 3 uM up to 50 mins by LCMS analysis 来源：ChEMBL 靶标：Liver External Id：CHEMBL4009530

实验名称：Stability in human plasma assessed as compound remaining at 5 uM after 1 hr by LCMS a... 来源：ChEMBL 靶标：Plasma External Id：CHEMBL4009531

实验名称：Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) by HTRF assay 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL4009528

实验名称：Stability in human liver microsomes at 3 uM up to 50 mins by LCMS analysis 来源：ChEMBL 靶标：Liver External Id：CHEMBL4009529

实验名称：Binding affinity to EGFR T790M mutant (unknown origin) assessed as covalent adduct fo... 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL4009513

实验名称：Inhibition of EGF-induced wild-type EGFR phosphorylation in human A431 cells at 10 uM... 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL4009542

实验名称：Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cells assessed as red... 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL4009541

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