HSL-IN-1

• 常用名: HSL-IN-1
• 英文名: HSL-IN-1
• CAS号: 2095156-13-9
• 分子量: 436.58
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₃BClF₃N₂O₄
• 熔点: N/A
• 闪点: N/A

HSL-IN-1用途

HSL-IN-1 (compound 24b) 是一种有效且具有口服活性的激素敏感脂肪酶 (HSL) 抑制剂 (IC50=2 nM),显著降低了活性代谢物负荷。

HSL-IN-1名称

• 英文名: HSL-IN-1

HSL-IN-1生物活性

• 描述: HSL-IN-1 (compound 24b) 是一种有效且具有口服活性的激素敏感脂肪酶 (HSL) 抑制剂 (IC50=2 nM),显著降低了活性代谢物负荷。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 靶点实验:

  IC50: 2 nM (Hormone sensitive lipase)[1]

• 参考文献:

  [1]. Ogiyama T, et al. Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation. Bioorg Med Chem. 2017 Apr 1;25(7):2234-2243.

HSL-IN-1物理化学性质

• 分子式: C₁₉H₁₃BClF₃N₂O₄
• 分子量: 436.58
• 外观性状: 固体
• 储存条件: 2-8°C，密封，干燥

HSL-IN-1靶点实验

查看更多实验

实验名称：Inhibition of HSL in rat adipocytes assessed as reduction in lipolysis by measuring g... 来源：ChEMBL 靶标：Hormone-sensitive lipase External Id：CHEMBL4044731

实验名称：Metabolic stability in rat liver microsomes assessed as parent compound remaining at ... 来源：ChEMBL 靶标：Liver External Id：CHEMBL3999940

实验名称：Inhibition of recombinant human HSL expressed in baculovirus infected sf9 insect cell... 来源：ChEMBL 靶标：Hormone-sensitive lipase External Id：CHEMBL4044730

实验名称：Inhibition of recombinant human HSL expressed in baculovirus infected sf9 cells using... 来源：ChEMBL 靶标：Hormone-sensitive lipase External Id：CHEMBL3999937

实验名称：Drug metabolism in human liver microsomes assessed as glutathione reactivity by measu... 来源：ChEMBL 靶标：Liver External Id：CHEMBL3999936

实验名称：Aqueous solubility of the compound in Japanese pharmacopoeia second fluid at pH 6.8 a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4044739

实验名称：Aqueous solubility of the compound in FaSSIF after 4 hrs by HPLC/UV analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4044740

实验名称：Antilipolytic activity in Wistar rat assessed as reduction in plasma glycerol AUC (0 ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3999943

实验名称：1-octanol/phosphate buffered saline distribution coefficient, log D of the compound a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4044737

实验名称：AUC (0 to 7 hrs) in Wistar rat at 3 mg/kg, po by LC-MS/MS analysis 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3999942

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