1-((2R,5S)-4-(6-chloro-2-(3-(dimethylamino)azetidin-1-yl)-8-fluoro-7-(6-methyl-1H-indazol-7-yl)quinazolin-4-yl)-2,5-dimethylpiperazin-1-yl)prop-2-en-1-one

• 常用名: 1-((2R,5S)-4-(6-chloro-2-(3-(dimethylamino)azetidin-1-yl)-8-fluoro-7-(6-methyl-1H-indazol-7-yl)quinazolin-4-yl)-2,5-dimethylpiperazin-1-yl)prop-2-en-1-one
• 英文名: 1-((2R,5S)-4-(6-chloro-2-(3-(dimethylamino)azetidin-1-yl)-8-fluoro-7-(6-methyl-1H-indazol-7-yl)quinazolin-4-yl)-2,5-dimethylpiperazin-1-yl)prop-2-en-1-one
• CAS号: 2098510-53-1
• 分子量: 577.1
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₃₄ClFN₈O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1-((2R,5S)-4-(6-chloro-2-(3-(dimethylamino)azetidin-1-yl)-8-fluoro-7-(6-methyl-1H-indazol-7-yl)quinazolin-4-yl)-2,5-dimethylpiperazin-1-yl)prop-2-en-1-one

物理化学性质

• 分子式: C₃₀H₃₄ClFN₈O
• 分子量: 577.1
• InChIKey: UOONYNWSXSDXOK-MSOLQXFVSA-N
• SMILES: C[C@@H]1CN([C@H](CN1C(=O)C=C)C)C2=NC(=NC3=C(C(=C(C=C32)Cl)C4=C(C=CC5=C4NN=C5)C)F)N6CC(C6)N(C)C

靶点实验

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实验名称：Stability in monkey whole blood assessed as half life by LC/MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5524359

实验名称：Stability in dog whole blood assessed as half life by LC/MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5524358

实验名称：Binding affinity to KRAS G12C mutant (unknown origin) measured after 3 mins 来源：ChEMBL 靶标：GTPase KRas External Id：CHEMBL5524357

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