1,6-Naphthyridine-6(5H)-ethanamine, 2-[[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl

• 常用名: 1,6-Naphthyridine-6(5H)-ethanamine, 2-[[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl
• 英文名: 1,6-Naphthyridine-6(5H)-ethanamine, 2-[[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl
• CAS号: 2102887-51-2
• 分子量: 506.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₃₂F₂N₈
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1,6-Naphthyridine-6(5H)-ethanamine, 2-[[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-7,8-dihydro-N,N-dimethyl

物理化学性质

• 分子式: C₂₇H₃₂F₂N₈
• 分子量: 506.6
• InChIKey: KGMVZSJAPXYTKH-UHFFFAOYSA-N
• SMILES: Cc1nc2c(F)cc(-c3nc(Nc4ccc5c(n4)CCN(CCN(C)C)C5)ncc3F)cc2n1C(C)C

靶点实验

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实验名称：LANCE Ultra ULight Assay from US Patent US10662186: "Substituted pyrimidines as cycli... 来源：BindingDB 靶标：N/A External Id：BindingDB_9135_1

实验名称：Clearance in BALB/c mouse at 3 mg/kg, iv measured upto 1440 mins by UPLC-MS/MS analys... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4305877

实验名称：Volume of distribution at steady state in BALB/c mouse at 3 mg/kg, iv measured upto 1... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4305876

实验名称：Half life in BALB/c mouse at 3 mg/kg, iv measured upto 1440 mins by UPLC-MS/MS analys... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4305875

实验名称：AUC (0 to t) in BALB/c mouse at 3 mg/kg, iv measured upto 1440 mins by UPLC-MS/MS ana... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4305874

实验名称：Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incuba... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4305871

实验名称：Inhibition of CYP2D6 in human liver microsomes using quinidine as substrate incubated... 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL4305870

实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 3 mg/kg, iv measured ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4305885

实验名称：Half life in Sprague-Dawley rat at 3 mg/kg, iv measured upto 1440 mins by UPLC-MS/MS ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4305884

实验名称：AUC (0 to t) in Sprague-Dawley rat at 3 mg/kg, iv measured upto 1440 mins by UPLC-MS/... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4305883

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