N-[(1-Fluorocyclopropyl)carbonyl]-3-Methyl-L-Valyl-(4r)-4-Hydroxy-N-[4-(4-Methyl-1,3-Thiazol-5-Yl)benzyl]-L-Prolinamide

• 常用名: N-[(1-Fluorocyclopropyl)carbonyl]-3-Methyl-L-Valyl-(4r)-4-Hydroxy-N-[4-(4-Methyl-1,3-Thiazol-5-Yl)benzyl]-L-Prolinamide
• 英文名: N-[(1-Fluorocyclopropyl)carbonyl]-3-Methyl-L-Valyl-(4r)-4-Hydroxy-N-[4-(4-Methyl-1,3-Thiazol-5-Yl)benzyl]-L-Prolinamide
• CAS号: 2135318-53-3
• 分子量: 516.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₃FN₄O₄S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[(1-Fluorocyclopropyl)carbonyl]-3-Methyl-L-Valyl-(4r)-4-Hydroxy-N-[4-(4-Methyl-1,3-Thiazol-5-Yl)benzyl]-L-Prolinamide

物理化学性质

• 分子式: C₂₆H₃₃FN₄O₄S
• 分子量: 516.6
• InChIKey: GFNCBUDQFXZVNN-SVFBPWRDSA-N
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)C2(F)CC2)C(C)(C)C)cc1

靶点实验

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实验名称：Distribution coefficient, logD of compound at pH 7.4 by chromatographic method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5368611

实验名称：Protein binding in human serum albumin assessed as fraction bound 来源：ChEMBL 靶标：Albumin External Id：CHEMBL5368612

实验名称：Inhibition of VBC in human HeLa cells expressing HRE-luciferase reporter gene assesse... 来源：ChEMBL 靶标：Elongin-B External Id：CHEMBL4219880

实验名称：Displacement of FAM-labeled HIF-1alpha peptide from VBC (unknown origin) by fluoresce... 来源：ChEMBL 靶标：Elongin-B External Id：CHEMBL4219881

实验名称：Binding affinity to VBC (unknown origin) assessed as association rate constant at 50 ... 来源：ChEMBL 靶标：Elongin-B External Id：CHEMBL4219888

实验名称：Chromatographic hydrophobicity index, log D of the compound at pH 7.4 by HPLC analysi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4219887

实验名称：Binding affinity to VBC (unknown origin) assessed as dissociation rate constant at 50... 来源：ChEMBL 靶标：Elongin-B External Id：CHEMBL4219889

实验名称：Antiproliferative activity against human HeLa cells assessed as reduction in cell pro... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL4219884

实验名称：Inhibition of VBC in human HeLa cells assessed as HIF-1alpha stabilization by measuri... 来源：ChEMBL 靶标：Elongin-B External Id：CHEMBL4219883

实验名称：Passive permeability of the compound in pH 7.4 PBS at 10 uM after 5 hrs by UPLC-MS/MS... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4219886

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