(4S)-4-(2-cyclopropylethynyl)-5,6-difluoro-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one

• 常用名: (4S)-4-(2-cyclopropylethynyl)-5,6-difluoro-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one
• 英文名: (4S)-4-(2-cyclopropylethynyl)-5,6-difluoro-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one
• CAS号: 214287-90-8
• 分子量: 316.22600
• 密度: 1.54g/cm3
• 沸点: 340.3ºC at 760 mmHg
• 分子式: C₁₄H₉F₅N₂O
• 熔点: N/A
• 闪点: 159.6ºC

名称

• 英文名: (4S)-4-(2-cyclopropylethynyl)-5,6-difluoro-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one

物理化学性质

• 密度: 1.54g/cm3
• 沸点: 340.3ºC at 760 mmHg
• 分子式: C₁₄H₉F₅N₂O
• 分子量: 316.22600
• 闪点: 159.6ºC
• 精确质量: 316.06400
• PSA: 44.62000
• LogP: 3.04890
• InChIKey: QCNJQJJFXFJVCX-ZDUSSCGKSA-N
• SMILES: O=C1Nc2ccc(F)c(F)c2C(C#CC2CC2)(C(F)(F)F)N1
• 蒸汽压: 8.67E-05mmHg at 25°C
• 折射率: 1.554

靶点实验

查看更多实验

实验名称：In vitro antiviral activity against HIV-1 (L100I). 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL704776

实验名称：Inhibition of HIV-1 reverse transcriptase. 来源：ChEMBL 靶标：Reverse transcriptase/RNaseH External Id：CHEMBL797511

实验名称：Effect of human plasma protein binding on antiviral efficacy. 来源：ChEMBL 靶标：Reverse transcriptase/RNaseH External Id：CHEMBL818462

实验名称：percentage of the free compound in tissue culture medium 来源：ChEMBL 靶标：N/A External Id：CHEMBL696522

实验名称：Antiviral activity toward K103N mutant HIV-1 virus as protein binding adjusted (PB ad... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL704394

实验名称：Antiviral activity was evaluated for the inhibition of wild-type RF strain of HIV-1 i... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL844945

实验名称：percentage of the free compound in human serum 来源：ChEMBL 靶标：N/A External Id：CHEMBL696521

实验名称：HIV Enzyme Data 来源：NIAID 靶标：N/A External Id：HIV Enzyme Data

实验名称：Antiviral activity against HIV-1 K103N mutant virus. 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL704395

实验名称：Compound was evaluated for the inhibition of HIV-1 Reverse transcriptase 来源：ChEMBL 靶标：Reverse transcriptase/RNaseH External Id：CHEMBL799147

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英文别名

• dpc 963