(E)-N-(4-(4-amino-3-(5-chloro-3-methylbenzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl)phenyl)-4-(dimethylamino)but-2-enamide

• 常用名: (E)-N-(4-(4-amino-3-(5-chloro-3-methylbenzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl)phenyl)-4-(dimethylamino)but-2-enamide
• 英文名: (E)-N-(4-(4-amino-3-(5-chloro-3-methylbenzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl)phenyl)-4-(dimethylamino)but-2-enamide
• CAS号: 2162198-61-8
• 分子量: 518.0
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₄ClN₇O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (E)-N-(4-(4-amino-3-(5-chloro-3-methylbenzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl)phenyl)-4-(dimethylamino)but-2-enamide

物理化学性质

• 分子式: C₂₆H₂₄ClN₇O₃
• 分子量: 518.0
• InChIKey: IJOGTDNCYKJLOQ-SNAWJCMRSA-N
• SMILES: CC1=C(OC2=C1C=C(C=C2)Cl)C3=C4C(=NN3C5=CC=C(C=C5)NC(=O)/C=C/CN(C)C)C(=O)NN=C4N

靶点实验

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实验名称：Irreversible inhibition of human FGFR1 using poly (Glu, Tyr)4:1 as substrate measured... 来源：ChEMBL 靶标：Fibroblast growth factor receptor 1 External Id：CHEMBL4313100

实验名称：Stability in rat blood assessed as parent compound remaining at 5 uM measured after 5... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4313099

实验名称：Glutathione reactivity in methanol/PBS assessed as compound-adduct formation at 500 n... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4313097

实验名称：Half life in mouse liver microsomes at 0.1 uM in presence of NADPH by LC-MS/MS analys... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4313096

实验名称：Kinetic solubility of the compound in pH 7.4 PBS by nephelometric method 来源：ChEMBL 靶标：N/A External Id：CHEMBL4313095

实验名称：Inhibition of recombinant full-length human Yes at 100 nM using poly(Glu, Tyr) 4:1 as... 来源：ChEMBL 靶标：Tyrosine-protein kinase Yes External Id：CHEMBL4313108

实验名称：Inhibition of recombinant human ARG (38 to end residues) at 100 nM using EAIYAAPFAKKK... 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL2 External Id：CHEMBL4313107

实验名称：Inhibition of recombinant human DDR1 V833L mutant (492 to end residues) at 100 nM usi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4313106

实验名称：Inhibition of human SIK (1 to 281 residues) at 100 nM using AMARAASAAALARRR as substr... 来源：ChEMBL 靶标：Serine/threonine-protein kinase SIK1 External Id：CHEMBL4313105

实验名称：Inhibition of recombinant human c-RAF Y340D/Y341D mutant (360 to end residues) at 100... 来源：ChEMBL 靶标：RAF proto-oncogene serine/threonine-protein kinase External Id：CHEMBL4313104

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