NLX-204

更新时间：2025-12-02 11:27:32

NLX-204结构式	常用名	NLX-204	英文名	NLX-204
	CAS号	2170405-10-2	分子量	409.862
	密度	N/A	沸点	N/A
	分子式	C₂₀H₂₂ClF₂N₃O₂	熔点	N/A
	MSDS	N/A	闪点	N/A

NLX-204用途

NLX-204(NLX204)是一种有效的,选择性的ERK1/2磷酸化,优选5-羟色胺5 HT1A受体激动剂,pEC50为9.37；显示出有希望的药代动力学特征,也能强烈刺激大鼠皮质中ERK1/2的磷酸化,并显示出高效(MED=0.16 mg/kg)和有效的抗抑郁样活性,完全消除了大鼠Porsolt试验中的不动性。

英文名	NLX-204

描述	NLX-204(NLX204)是一种有效的,选择性的ERK1/2磷酸化,优选5-羟色胺5 HT1A受体激动剂,pEC50为9.37；显示出有希望的药代动力学特征,也能强烈刺激大鼠皮质中ERK1/2的磷酸化,并显示出高效(MED=0.16 mg/kg)和有效的抗抑郁样活性,完全消除了大鼠Porsolt试验中的不动性。
参考文献	References 1. Sniecikowska J, et al. J Med Chem. 2019 Feb 5. doi: 10.1021/acs.jmedchem.9b00062. View Related Products by Target Histamine Receptor

分子式	C₂₀H₂₂ClF₂N₃O₂
分子量	409.862

实验名称：Inhibition of muscarinic M1 receptor (unknown origin) at 10 uM relative to control
来源：ChEMBL
靶标：Muscarinic acetylcholine receptor M1
External Id：CHEMBL4707389

实验名称：Inhibition of histamine H4 receptor (unknown origin) at 1 uM relative to control
来源：ChEMBL
靶标：Histamine H4 receptor
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实验名称：Inhibition of muscarinic M3 receptor (unknown origin) at 10 uM relative to control
来源：ChEMBL
靶标：Muscarinic acetylcholine receptor M3
External Id：CHEMBL4707391

实验名称：Inhibition of muscarinic M2 receptor (unknown origin) at 10 uM relative to control
来源：ChEMBL
靶标：Muscarinic acetylcholine receptor M2
External Id：CHEMBL4707390

实验名称：Inhibition of delta 2-type opioid receptor (unknown origin) at 10 uM relative to cont...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4707393

实验名称：Inhibition of muscarinic M4 receptor (unknown origin) at 1 uM relative to control
来源：ChEMBL
靶标：Muscarinic acetylcholine receptor M4
External Id：CHEMBL4707392

实验名称：Inhibition of mu opioid receptor (unknown origin) at 10 uM relative to control
来源：ChEMBL
靶标：Mu-type opioid receptor
External Id：CHEMBL4707395

实验名称：Inhibition of kappa opioid receptor (unknown origin) at 10 uM relative to control
来源：ChEMBL
靶标：Kappa-type opioid receptor
External Id：CHEMBL4707394

实验名称：Inhibition of dopamine D2S receptor (unknown origin) at 10 uM relative to control
来源：ChEMBL
靶标：D(2) dopamine receptor
External Id：CHEMBL4707381

实验名称：Inhibition of dopamine D1 receptor (unknown origin) at 10 uM relative to control
来源：ChEMBL
靶标：D(1A) dopamine receptor
External Id：CHEMBL4707380

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