N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-N-[(1R,2R)-1-[(cyclopropylsulfonyl)carbamoyl]-2-(difluoromethyl)cyclopropyl]-L-prolinamide

• 常用名: N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-N-[(1R,2R)-1-[(cyclopropylsulfonyl)carbamoyl]-2-(difluoromethyl)cyclopropyl]-L-prolinamide
• 英文名: N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-N-[(1R,2R)-1-[(cyclopropylsulfonyl)carbamoyl]-2-(difluoromethyl)cyclopropyl]-L-prolinamide
• CAS号: 2173403-27-3
• 分子量: 772.3
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₄₄ClF₂N₅O₉S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-N-[(1R,2R)-1-[(cyclopropylsulfonyl)carbamoyl]-2-(difluoromethyl)cyclopropyl]-L-prolinamide

物理化学性质

• 分子式: C₃₄H₄₄ClF₂N₅O₉S
• 分子量: 772.3
• InChIKey: PSVSXONHXYMVQH-GGFAASIMSA-N
• SMILES: CC(C)(C)[C@@H](C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@]2(C[C@H]2C(F)F)C(=O)NS(=O)(=O)C3CC3)OC4=NC=C(C5=C4C=C(C=C5)Cl)OC)NC(=O)OC(C)(C)C

靶点实验

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实验名称：Inhibition of recombinant full length HCV genotype 1a NS3/4A protease (1027 to 1711 r... 来源：ChEMBL 靶标：Genome polyprotein External Id：CHEMBL4145025

实验名称：Permeability from basolateral to apical side in human Caco2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4145034

实验名称：AUC in Sprague-Dawley rat at 15 mg/kg, po administered via gavage or 5 mg/kg, iv admi... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4145030

实验名称：Elimination half life in Sprague-Dawley rat at 15 mg/kg, po administered via gavage o... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4145031

实验名称：Permeability from apical to basolateral side in human Caco2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4145033

实验名称：Antiviral activity against HCV genotype 1b Con1 infected in human HuH7.5 cells assess... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL4145026

实验名称：Half life in human liver microsomes by LC/MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4145027

实验名称：Oral bioavailability in Sprague-Dawley rat at 15 mg/kg, administered via gavage by LC... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4145028

实验名称：Clearance in Sprague-Dawley rat at 15 mg/kg, po administered via gavage or 5 mg/kg, i... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4145029

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