Carbamic acid, [8-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]octyl]-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester

• 常用名: Carbamic acid, [8-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]octyl]-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
• 英文名: Carbamic acid, [8-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]octyl]-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
• CAS号: 217788-74-4
• 分子量: 678.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₅H₅₈N₄O₇S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: Carbamic acid, [8-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]octyl]-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester

物理化学性质

• 分子式: C₃₅H₅₈N₄O₇S
• 分子量: 678.9
• InChIKey: UHODULUFNVILLN-CKOCRFSOSA-N
• SMILES: COC1C(OC(=O)NCCCCCCCCNC(=O)CCCCC2SCC3NC(=O)NC32)CCC2(CO2)C1C1(C)OC1CC=C(C)C

靶点实验

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实验名称：Binding affinity to MetAP2 in compound pre-treated HUVEC at 0.1 uM after 48 hrs by We... 来源：ChEMBL 靶标：Methionine aminopeptidase 2 External Id：CHEMBL3238831

实验名称：Binding affinity to MetAP2 in fumagillin-pretreated HUVEC at 0.1 uM by Western blotti... 来源：ChEMBL 靶标：Methionine aminopeptidase 2 External Id：CHEMBL3238830

实验名称：Permeability in human HepG2 assessed as compound bound MetAP2 level at 0.1 uM by West... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL3238835

实验名称：Permeability in HUVEC assessed as compound bound MetAP2 level at 0.1 uM by Western bl... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL3238834

实验名称：Permeability in HUVEC assessed as biotin detection by measuring denatured MetAP2 pull... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL3239745

实验名称：Permeability in HUVEC assessed as biotin detection by measuring MetAP2 pull down by m... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL3239744

实验名称：Antiproliferative against human A549 cells assessed as cell viability up to 1000 nM a... 来源：ChEMBL 靶标：A549 External Id：CHEMBL3238825

实验名称：Antiproliferative against human HepG2 cells assessed as cell viability up to 1000 nM ... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL3238827

实验名称：Antiproliferative against human Bel7402 cells assessed as cell viability up to 1000 n... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3238826

实验名称：Binding affinity to MetAP2 in HUVEC at 0.1 uM by Western blotting analysis 来源：ChEMBL 靶标：Methionine aminopeptidase 2 External Id：CHEMBL3238829

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