DI-404

• 常用名: DI-404
• 英文名: DI-404
• CAS号: 2187412-79-7
• 分子量: 713.29
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₅H₄₅ClN₆O₆S
• 熔点: N/A
• 闪点: N/A

DI-404用途

DI-404是一种高亲和力拟肽DCN1-UBC12蛋白-蛋白相互作用抑制剂(Kd=6.9nM)。DI-404与其它cullin成员相比有效且选择性地抑制cullin 3的nedylation。

DI-404名称

• 英文名: DI-404

DI-404生物活性

• 描述: DI-404是一种高亲和力拟肽DCN1-UBC12蛋白-蛋白相互作用抑制剂(Kd=6.9nM)。DI-404与其它cullin成员相比有效且选择性地抑制cullin 3的nedylation。
• 参考文献: 1. ZHou HB, Zhou W, Zhou B, Liu L, Chern TR, Chinnaswamy K, Lu J, Bernard D, Yang C, Li S, Wang M, Stuckey JA, Sun Y, Wang S. High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2018 Feb 13. doi: 10.1021/acs.jmedchem.7b01455. [Epub ahead of print] PubMed PMID: 29438612.

DI-404物理化学性质

• 分子式: C₃₅H₄₅ClN₆O₆S
• 分子量: 713.29

DI-404靶点实验

查看更多实验

实验名称：Binding affinity to biotin labeled recombinant N-terminal His6-tagged human DCN1 (58 ... 来源：ChEMBL 靶标：DCN1-like protein 1 External Id：CHEMBL4121125

实验名称：Inhibition of DCN1-mediated CUL3 neddylation in human H2170 cells after 16 hrs by Wes... 来源：ChEMBL 靶标：DCN1-like protein 1 External Id：CHEMBL4121157

实验名称：Inhibition of DCN1-mediated CUL4A neddylation in human H2170 cells at 0.1 to 10 uM af... 来源：ChEMBL 靶标：DCN1-like protein 1 External Id：CHEMBL4121158

实验名称：Binding affinity to biotin labeled recombinant N-terminal His6-tagged human DCN1 (58 ... 来源：ChEMBL 靶标：DCN1-like protein 1 External Id：CHEMBL4121123

实验名称：Effect on UBC12 levels in human NCI-H2170 cells at 5 to 10 uM after 24 hrs by Western... 来源：ChEMBL 靶标：NCI-H2170 External Id：CHEMBL4121156

实验名称：Binding affinity to biotin labeled recombinant N-terminal His6-tagged human DCN1 (58 ... 来源：ChEMBL 靶标：DCN1-like protein 1 External Id：CHEMBL4121124

实验名称：Competitive FP Binding Assay from US Patent US12012467: "Small molecule DCN1 inhibito... 来源：BindingDB 靶标：N/A External Id：BindingDB_12116_1

实验名称：Inhibition of DCN1-mediated CUL2 neddylation in human H2170 cells at 0.1 to 10 uM aft... 来源：ChEMBL 靶标：DCN1-like protein 1 External Id：CHEMBL4121133

实验名称：Inhibition of DCN1-mediated CUL4A neddylation in human H2170 cells assessed as increa... 来源：ChEMBL 靶标：DCN1-like protein 1 External Id：CHEMBL4121134

实验名称：Inhibition of DCN1-mediated CUL3 neddylation in human H2170 cells assessed as increas... 来源：ChEMBL 靶标：DCN1-like protein 1 External Id：CHEMBL4121131

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