KB-141

• 常用名: KB-141
• 英文名: KB-141
• CAS号: 219691-94-8
• 分子量: 355.212
• 密度: 1.4±0.1 g/cm3
• 沸点: 464.7±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₆Cl₂O₄
• 熔点: N/A
• 闪点: 234.9±28.7 °C

KB-141用途

KB-141(KB141)是一种有效的选择性甲状腺激素受体TRβ激动剂(IC50=1.1 nM),与hTRβ结合的亲和力比hTRα高14倍；选择性降低血浆胆固醇水平,也增加全身氧消耗(MVO2)在小鼠和大鼠中。

KB-141名称

• 英文名: KB-141

KB-141生物活性

• 描述: KB-141(KB141)是一种有效的选择性甲状腺激素受体TRβ激动剂(IC50=1.1 nM),与hTRβ结合的亲和力比hTRα高14倍；选择性降低血浆胆固醇水平,也增加全身氧消耗(MVO2)在小鼠和大鼠中。
• 参考文献: References 1. Grover GJ, et al. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10067-72. 2. Johansson L, et al. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10297-302. 3. Grover GJ, et al. Cardiovasc Drug Rev. 2005 Summer;23(2):133-48. Review. 4. Ye L, et al. J Med Chem. 2003 Apr 24;46(9):1580-8. View Related Products by Target Thyroid Hormone Receptor (THR)

KB-141物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 464.7±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₆Cl₂O₄
• 分子量: 355.212
• 闪点: 234.9±28.7 °C
• 精确质量: 354.042572
• LogP: 4.75
• InChIKey: OZYQIQVPUZANTM-UHFFFAOYSA-N
• SMILES: CC(C)c1cc(Oc2c(Cl)cc(CC(=O)O)cc2Cl)ccc1O
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.606

KB-141靶点实验

查看更多实验

实验名称：TRbeta-Binding Assay and Thyroid Response Element (TRAFbeta1) Reporter Assay. from Ar... 来源：BindingDB 靶标：N/A External Id：BindingDB_2280_2

实验名称：Toxicity in Sprague-Dawley rat assessed as suppression of thyroid hormone axis measur... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL966824

实验名称：Inhibitory concentration against cloned human thyroid hormone receptor alpha 1 来源：ChEMBL 靶标：Thyroid hormone receptor alpha External Id：CHEMBL880611

实验名称：TRalpha-Binding Assay and Thyroid Response Element (TRAFalpha1) Reporter Assay. from ... 来源：BindingDB 靶标：N/A External Id：BindingDB_2280_1

实验名称：Toxicity in Sprague-Dawley rat assessed as suppression of thyroid hormone axis measur... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL966823

实验名称：Toxicity in Sprague-Dawley rat assessed as suppression of thyroid hormone axis measur... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL966825

实验名称：Ratio of IC50 of thyroid hormone receptor alpha 1 to that of thyroid hormone receptor... 来源：ChEMBL 靶标：Thyroid hormone receptor beta External Id：CHEMBL884148

实验名称：Toxicity in Sprague-Dawley rat assessed as suppression of thyroid hormone axis measur... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL981669

实验名称：Toxicity in Sprague-Dawley rat assessed as suppression of thyroid hormone axis measur... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL981668

实验名称：Toxicity in Sprague-Dawley rat assessed as suppression of thyroid hormone axis measur... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL981671

共95条，当前第1页，共10页

1

2

3

4

5

KB-141英文别名

• KB-141
• 3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic acid
• [3,5-Dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]acetic acid