DNDI-8219

• 常用名: DNDI-8219
• 英文名: DNDI-8219
• CAS号: 2222660-40-2
• 分子量: 345.234
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₃H₁₀F₃N₃O₅
• 熔点: N/A
• 闪点: N/A

DNDI-8219用途

DNDI-8219是一种新型有效的口服活性抗利什曼原虫药物,对杜氏利什曼原虫(L.don)的IC50为0.19 uM；对L.inf和T.cruzi的IC050为0.53和0.15 uM,在更严格的利什曼原虫婴儿仓鼠模型,具有更好的溶解性和药代动力学特性,以及最小的hERG抑制。

DNDI-8219名称

• 英文名: DNDI-8219

DNDI-8219生物活性

• 描述: DNDI-8219是一种新型有效的口服活性抗利什曼原虫药物,对杜氏利什曼原虫(L.don)的IC50为0.19 uM；对L.inf和T.cruzi的IC050为0.53和0.15 uM,在更严格的利什曼原虫婴儿仓鼠模型,具有更好的溶解性和药代动力学特性,以及最小的hERG抑制。
• 参考文献: References 1. Thompson AM, et al. J Med Chem. 2018 Mar 22;61(6):2329-2352. View Related Products by Target Parasite

DNDI-8219物理化学性质

• 分子式: C₁₃H₁₀F₃N₃O₅
• 分子量: 345.234

DNDI-8219靶点实验

查看更多实验

实验名称：Protein binding in hamster plasma at 2 uM after 4 to 6 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4023876

实验名称：Protein binding in human plasma at 2 uM after 4 to 6 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：Plasma External Id：CHEMBL4023877

实验名称：Protein binding in mouse plasma at 2 uM after 4 to 6 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：Plasma External Id：CHEMBL4023874

实验名称：Protein binding in rat plasma at 2 uM after 4 to 6 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：Plasma External Id：CHEMBL4023875

实验名称：Apparent permeability from apical to basolateral side in MDCK cells harboring MDR1 at... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4023870

实验名称：Apparent permeability from basolateral to apical side in MDCK cells harboring MDR1 at... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4023871

实验名称：Genotoxicity in Salmonella typhimurium TA98 at 1.5 to 1000 ug/well in absence of rat ... 来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhimurium External Id：CHEMBL4023880

实验名称：Genotoxicity in Salmonella typhimurium TA100 at 1.5 to 1000 ug/well in absence of rat... 来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhimurium External Id：CHEMBL4023881

实验名称：Genotoxicity in Salmonella typhimurium TA98 at 1.5 to 1000 ug/well in presence of rat... 来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhimurium External Id：CHEMBL4023878

实验名称：Genotoxicity in Salmonella typhimurium TA100 at 1.5 to 1000 ug/well in presence of ra... 来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhimurium External Id：CHEMBL4023879

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