6-[4-(4-{4-[2-(difluoromethyl)-1H-1,3-benzodiazol-1-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-4-oxobutanamido]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]hexanamide

• 常用名: 6-[4-(4-{4-[2-(difluoromethyl)-1H-1,3-benzodiazol-1-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-4-oxobutanamido]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]hexanamide
• 英文名: 6-[4-(4-{4-[2-(difluoromethyl)-1H-1,3-benzodiazol-1-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-4-oxobutanamido]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]hexanamide
• CAS号: 2227423-34-7
• 分子量: 884.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₂H₄₆F₂N₁₂O₈
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 6-[4-(4-{4-[2-(difluoromethyl)-1H-1,3-benzodiazol-1-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-4-oxobutanamido]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]hexanamide

物理化学性质

• 分子式: C₄₂H₄₆F₂N₁₂O₈
• 分子量: 884.9
• InChIKey: MKRKZQMIXDTHOO-UHFFFAOYSA-N
• SMILES: O=C(CCC(=O)N1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1)NCCCCCC(=O)Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O

靶点实验

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实验名称：Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 1 hr by Kinase... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL4152726

实验名称：Cell cycle arrest in human HepG2 cells assessed as accumulation at S phase at 5 uM af... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4152747

实验名称：Cell cycle arrest in human HepG2 cells assessed as accumulation at G2/M phase at 5 uM... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4152748

实验名称：Cell cycle arrest in human HepG2 cells assessed as accumulation at G0/G1 phase at 10 ... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4152749

实验名称：Cell cycle arrest in human HepG2 cells assessed as accumulation at S phase at 10 uM a... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4152750

实验名称：Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 25 uM... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4152743

实验名称：Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 25 u... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4152744

实验名称：Induction of apoptosis in human HepG2 cells assessed as viable cells at 25 uM after 2... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4152745

实验名称：Cell cycle arrest in human HepG2 cells assessed as accumulation at G0/G1 phase at 5 u... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4152746

实验名称：Induction of autophagy in GFP-LC3 transfected human HepG2 cells assessed as increase ... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4152755

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