MFN2 agonist B-A l

• 常用名: MFN2 agonist B-A l
• 英文名: MFN2 agonist B-A l
• CAS号: 2230047-87-5
• 分子量: 399.557
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₉N₅OS
• 熔点: N/A
• 闪点: N/A

MFN2 agonist B-A l用途

MFN2激动剂B-A l是MFN2肽-肽界面的小分子模拟物,变构激活MFN2并促进线粒体融合,EC50为3 nM；有效刺激MFN2缺陷细胞中的线粒体融合,竞争MFN2 HR2上的小肽结合互动网站,通过改善线粒体运动障碍,片段化,去极化和结块激活内源性线粒体融合蛋白来纠正由无功能MFN2突变体诱导的线粒体损伤；使MFN2 Thr105→Met105小鼠的坐骨神经内的轴突线粒体运输正常化。

MFN2 agonist B-A l名称

• 英文名: MFN2 agonist B-A l

MFN2 agonist B-A l生物活性

• 描述: MFN2激动剂B-A l是MFN2肽-肽界面的小分子模拟物,变构激活MFN2并促进线粒体融合,EC50为3 nM；有效刺激MFN2缺陷细胞中的线粒体融合,竞争MFN2 HR2上的小肽结合互动网站,通过改善线粒体运动障碍,片段化,去极化和结块激活内源性线粒体融合蛋白来纠正由无功能MFN2突变体诱导的线粒体损伤；使MFN2 Thr105→Met105小鼠的坐骨神经内的轴突线粒体运输正常化。
• 参考文献: References 1. Rocha AG, et al. Science. 2018 Apr 20;360(6386):336-341. View Related Products by Target Other Targets

MFN2 agonist B-A l物理化学性质

• 分子式: C₂₁H₂₉N₅OS
• 分子量: 399.557

MFN2 agonist B-A l靶点实验

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实验名称：Stability in human plasma at 2 uM after 120 mins by LC-MS/MS analysis relative to con... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4618553

实验名称：Effective permeability by PAMPA method 来源：ChEMBL 靶标：N/A External Id：CHEMBL4618552

实验名称：Half life in human liver microsomes at 1 uM by by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4618555

实验名称：Stability in mouse plasma at 2 uM after 120 mins by LC-MS/MS analysis relative to con... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4618554

实验名称：Half life in mouse liver microsomes at 1 uM by by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4618556

实验名称：Activation of mitofusin in cultured MFN2-deficient mouse fibroblasts assessed as indu... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4618558

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