MEDS433

• 常用名: MEDS433
• 英文名: MEDS433
• CAS号: 2241027-61-0
• 分子量: 401.321
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₁F₄N₃O₂
• 熔点: N/A
• 闪点: N/A

MEDS433用途

MEDS433是一种有效的DHODH抑制剂,IC50为1.2 nM(hDHODH),在纳摩尔范围内抑制HSV-1和HSV-2的体外复制。

MEDS433名称

• 英文名: MEDS433

MEDS433生物活性

• 描述: MEDS433是一种有效的DHODH抑制剂,IC50为1.2 nM(hDHODH),在纳摩尔范围内抑制HSV-1和HSV-2的体外复制。
• 参考文献: 1. Luganini A, et al. Antiviral Res. 2021 May;189:105057. 2. Stefano Sainas, et al. J Med Chem. 2018 Jul 26;61(14):6034-6055.

MEDS433物理化学性质

• 分子式: C₂₀H₁₁F₄N₃O₂
• 分子量: 401.321
• InChIKey: JIIXZPWFDKPNKW-UHFFFAOYSA-N
• SMILES: O=C(Nc1c(F)c(F)c(-c2ccccc2)c(F)c1F)c1c(=O)[nH]n2ccccc12

MEDS433靶点实验

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实验名称：Inhibition of recombinant N-terminal GST-tagged human DHODH (31 to 395 residues) expr... 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL4137384

实验名称：Antiproliferative activity against human Jurkat T cells assessed as DNA content after... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL4137385

实验名称：Stability of the compound in human serum assessed as compound remaining at 37 degC af... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4137383

实验名称：Solubility of the compound in PBS at pH 7.4 at 1 mg after 24 hrs in presence of 2% DM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4137392

实验名称：n-Octanol/PBS distribution coefficient, log D of the compound at pH 7.4 after 20 mins... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4137393

实验名称：Solubility of the compound in PBS at pH 7.4 at 1 mg after 24 hrs by HPLC-UV analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4137391

实验名称：Immunosuppressive activity against human PBMC assessed as inhibition of PHA-stimulate... 来源：ChEMBL 靶标：PBMC External Id：CHEMBL4137388

实验名称：Immunosuppressive activity against human PBMC assessed as inhibition of PHA-stimulate... 来源：ChEMBL 靶标：PBMC External Id：CHEMBL4137389

实验名称：Antiproliferative activity against human Jurkat T cells assessed as DNA content after... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL4137386

实验名称：Cytotoxicity against human Jurkat T cells assessed as compound concentration required... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL4137387

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