1-[3-[4-Amino-3-[5-(2-hydroxypropan-2-yl)-1-methylpyrazol-3-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one

• 常用名: 1-[3-[4-Amino-3-[5-(2-hydroxypropan-2-yl)-1-methylpyrazol-3-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
• 英文名: 1-[3-[4-Amino-3-[5-(2-hydroxypropan-2-yl)-1-methylpyrazol-3-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
• CAS号: 2243322-79-2
• 分子量: 410.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₆N₈O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1-[3-[4-Amino-3-[5-(2-hydroxypropan-2-yl)-1-methylpyrazol-3-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one

物理化学性质

• 分子式: C₂₀H₂₆N₈O₂
• 分子量: 410.5
• InChIKey: GLPYJCCEPJPDOB-UHFFFAOYSA-N
• SMILES: C=CC(=O)N1CCCC(n2nc(-c3cc(C(C)(C)O)n(C)n3)c3c(N)ncnc32)C1

靶点实验

查看更多实验

实验名称：Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 resid... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK2 External Id：CHEMBL4402146

实验名称：Antiproliferative activity against human HEL cells harboring JAK2 V617F mutant measur... 来源：ChEMBL 靶标：HEL External Id：CHEMBL4402147

实验名称：Inhibition of recombinant human GST-tagged JAK1 catalytic domain (866 to 1154 residue... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK1 External Id：CHEMBL4402148

实验名称：Inhibition of recombinant human GST-tagged JAK3 catalytic domain (781 to 1124 residue... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK3 External Id：CHEMBL4402149

实验名称：Selectivity ratio of IC50 for recombinant human GST-tagged JAK1 catalytic domain (866... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4402150

实验名称：Selectivity ratio of IC50 for recombinant human GST-tagged JAK3 catalytic domain (781... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4402151

实验名称：Cytotoxicity against IL-4 induced JAK1/3 activated human THP1 cells preincubated for ... 来源：ChEMBL 靶标：THP-1 External Id：CHEMBL4402153

实验名称：Inhibition of JAK2 in human TF1 cells assessed as reduction in GM-CSF-induced JAK2 au... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK2 External Id：CHEMBL4402162

实验名称：Inhibition of JAK1/3 in human THP1 cells assessed as reduction in IL4-induced STAT6 p... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK1 External Id：CHEMBL4402163

实验名称：Anti-inflammatory activity in dinitrofluorobenzene-induced Balb/c mouse delayed-type ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4402165

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