TUG-1375

• 常用名: TUG-1375
• 英文名: TUG-1375
• CAS号: 2247372-59-2
• 分子量: 442.92
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₁₉ClN₂O₄S
• 熔点: N/A
• 闪点: N/A

TUG-1375用途

TUG-1375 是一种游离脂肪酸受体 2 (FFA2/GPR43) 激动剂,pKi 值为 6.69。TUG-1375 对 FFA3,FFA4,PPARα,PPARγ,PPARδ,LXRα 或 LXRβ 无作用。

TUG-1375名称

• 中文名: TUG-1375
• 英文名: TUG-1375

TUG-1375生物活性

• 描述: TUG-1375 是一种游离脂肪酸受体 2 (FFA2/GPR43) 激动剂,pKi 值为 6.69。TUG-1375 对 FFA3,FFA4,PPARα,PPARγ,PPARδ,LXRα 或 LXRβ 无作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 靶点实验:

  pKi: 6.69 (FFA2)[1]

• 体外研究: TUG-1375在cAMP FFA2测定中显示pEC50为7.11,对小鼠FFA2直向同源物也有活性(pEC50,在cAMP测定中为6.44±0.13)[1]。
• 参考文献:

  [1]. Hansen AH, et al. Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8;61(21):9534-9550.

TUG-1375物理化学性质

• 分子式: C₂₂H₁₉ClN₂O₄S
• 分子量: 442.92
• InChIKey: RZAMDGBOOPJHJQ-GHTZIAJQSA-N
• SMILES: Cc1noc(C)c1-c1ccc(C(=O)N2C(C(=O)O)CSC2c2ccccc2Cl)cc1
• 储存条件: 2-8℃

TUG-1375靶点实验

查看更多实验

实验名称：Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta... 来源：ChEMBL 靶标：Free fatty acid receptor 2 External Id：CHEMBL4158157

实验名称：Agonist activity at FFA3R (unknown origin) up to 100 uM 来源：ChEMBL 靶标：Free fatty acid receptor 3 External Id：CHEMBL4158164

实验名称：Agonist activity at human FFA1R expressed in HEK293 cells assessed as induction of ca... 来源：ChEMBL 靶标：Free fatty acid receptor 1 External Id：CHEMBL4158165

实验名称：Antagonist activity at human FFA1 receptor expressed in HEK293 cells assessed as inhi... 来源：ChEMBL 靶标：Free fatty acid receptor 1 External Id：CHEMBL4158166

实验名称：Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduct... 来源：ChEMBL 靶标：Free fatty acid receptor 2 External Id：CHEMBL4158159

实验名称：Agonist activity to FFA2R in human neutrophils assessed as induction of cell migratio... 来源：ChEMBL 靶标：Free fatty acid receptor 2 External Id：CHEMBL4158199

实验名称：Agonist activity to FFA2R in human neutrophils assessed as induction of cell migratio... 来源：ChEMBL 靶标：Free fatty acid receptor 2 External Id：CHEMBL4158200

实验名称：Agonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isopro... 来源：ChEMBL 靶标：Free fatty acid receptor 2 External Id：CHEMBL4158202

实验名称：AUC (0 to infinity) in Balb/c mouse at 5 mg/kg, iv by HPLC-MS/MS analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4158187

实验名称：Volume of distribution in Balb/c mouse at 5 mg/kg, iv by HPLC-MS/MS analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4158188

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