N-(3-乙酰基-4-(2-羟基-3-(异丙基氨基)丙氧基)苯基)乙酰胺

更新时间：2024-01-11 14:44:33

N-(3-乙酰基-4-(2-羟基-3-(异丙基氨基)丙氧基)苯基)乙酰胺结构式	常用名	N-(3-乙酰基-4-(2-羟基-3-(异丙基氨基)丙氧基)苯基)乙酰胺	英文名	Diacetolol
	CAS号	22568-64-5	分子量	308.37
	密度	1.2±0.1 g/cm3	沸点	548.8±50.0 °C at 760 mmHg
	分子式	C₁₆H₂₄N₂O₄	熔点	N/A
	MSDS	N/A	闪点	285.7±30.1 °C

用途

双丙酮醇是β肾上腺素受体阻断剂阿塞布洛尔(HY-17497)的活性代谢产物[1]。

中文名	醋丁洛尔杂质B
英文名	rac Diacetolol
中文别名	醋丁洛尔EP杂质B
英文别名	更多

描述	双丙酮醇是β肾上腺素受体阻断剂阿塞布洛尔(HY-17497)的活性代谢产物[1]。
相关类别	研究领域 >> 心血管疾病研究领域 >> 内分泌
参考文献	[1]. B Basil, R Jordan, et al. Pharmacological properties of diacetolol (M & B 16,942), a major metabolite of acebutolol. Eur J Pharmacol. 1982 May 7;80(1):47-56.

密度	1.2±0.1 g/cm3
沸点	548.8±50.0 °C at 760 mmHg
分子式	C₁₆H₂₄N₂O₄
分子量	308.37
闪点	285.7±30.1 °C
精确质量	308.173615
PSA	91.15000
LogP	0.89
蒸汽压	0.0±1.6 mmHg at 25°C
折射率	1.551
储存条件	2-8°C

毒性英文版

危险品运输编码	NONH for all modes of transport
海关编码	2924299090

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Using supported liquid extraction together with cellobiohydrolase chiral stationary phases-based liquid chromatography with tandem mass spectrometry for enantioselective determination of acebutolol and its active metabolite diacetolol in spiked human plasma.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(3) , 173-80, (2009)

A high through-put, sensitive, and enantioselective LC-MS/MS-based bioanalytical method was developed and validated for the simultaneous determination of individual acebutolol (AC) and its active meta...

Acebutolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects.

Pharmacotherapy 6(2) , 45-63, (1986)

Acebutolol is a new hydrophilic, cardioselective beta-adrenergic-blocking agent that possesses partial agonist and membrane-stabilizing activities. In the treatment of mild to moderate essential hyper...

Preliminary study of the disposition in man of acebutolol and its metabolite, diacetolol, using a new stereoselective hplc method.

J. Pharm. Pharmacol. 36(4) , 276-7, (1984)

A new stereospecific hplc method that is capable of simultaneously quantitating the S-(-)- and R-(+)-enantiomers of acebutolol and its major metabolite, diacetolol, in plasma and urine, is described. ...

N-{3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide

N-{3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetami de

Acebutolol impurity B

N-{3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide

N-{3-Acetyl-4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl}acetamide

Acetamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-

Diacetolol

EINECS 245-088-3