新甘草酚

• 常用名: 新甘草酚
• 英文名: Neoglycyrol
• CAS号: 23013-84-5
• 分子量: 366.364
• 密度: 1.4±0.1 g/cm3
• 沸点: 493.1±45.0 °C at 760 mmHg
• 分子式: C₂₁H₁₈O₆
• 熔点: 263.5-265℃
• 闪点: 252.0±28.7 °C

新甘草酚用途

Neoglycyrol 新甘草酚从甘草 (Glycyrrhiza uralensis Fisch) 的根中分离。Neoglycyrol 是传统专利药通脉养心丸 (TMYXP) 中筛选出一种潜在的心肌保护活性化合物。

新甘草酚名称

• 中文名: 甘草酚
• 英文名: glycyrol

新甘草酚生物活性

• 描述: Neoglycyrol 新甘草酚从甘草 (Glycyrrhiza uralensis Fisch) 的根中分离。Neoglycyrol 是传统专利药通脉养心丸 (TMYXP) 中筛选出一种潜在的心肌保护活性化合物。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Wang CL, et al. Chemical studies of coumarins from Glycyrrhiza uralensis Fisch. Yao Xue Xue Bao. 1991;26(2):147-51.

  [2]. Tao S, et al. Screening of active compounds with myocardial protective effects from Tongmai Yangxin pill. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 Mar;44(2):145-53.

新甘草酚物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 493.1±45.0 °C at 760 mmHg
• 熔点: 263.5-265℃
• 分子式: C₂₁H₁₈O₆
• 分子量: 366.364
• 闪点: 252.0±28.7 °C
• 精确质量: 366.110352
• PSA: 93.04000
• LogP: 5.45
• InChIKey: LWESBHWAOZORCQ-UHFFFAOYSA-N
• SMILES: COc1c(CC=C(C)C)c(O)cc2oc(=O)c3c4ccc(O)cc4oc3c12
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.667
• 储存条件: 2-8C

新甘草酚靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Body weight of the fasted diabetic KK-Ay mice on day 10 was measured 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL711375

实验名称：Body weight of the non-fasted diabetic KK-Ay mice on day 0 was measured 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL711533

实验名称：Body weight of the non-fasted diabetic KK-Ay mice on day 7 was measured 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL711535

实验名称：Body weight of the non-fasted diabetic KK-Ay mice on day 4 was measured 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL711534

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Bas... 来源：Broad Institute 靶标：N/A External Id：2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2

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新甘草酚英文别名

• 3,9-Dihydroxy-1-methoxy-2-(3-methyl-but-2-enyl)-benzofuro[3,2-c][1]benzopyran-6-one
• 3,9-dihydroxy-1-methoxy-2-prenylcoumestan
• glycyrol
• 3,9-Dihydroxy-1-methoxy-2-(3-methyl-2-buten-1-yl)-6H-[1]benzofuro[3,2-c]chromen-6-one
• 3,9-dihydroxy-1-methoxy-2-isopentenylcoumestane
• 3,9-dihydroxy-1-methoxy-2-(3-methylbut-2-en-1-yl)-6H-[1]benzofuro[3,2-c]chromen-6-one
• 3,9-dihydroxy-1-methoxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one
• HMS2270J05