(7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide

• 常用名: (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide
• 英文名: (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide
• CAS号: 2307262-96-8
• 分子量: 597.7
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₂H₄₇N₅O₆
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide

物理化学性质

• 分子式: C₃₂H₄₇N₅O₆
• 分子量: 597.7
• InChIKey: UGEFECOTMZPOER-KCHLEUMXSA-N
• SMILES: C1CCOC2=CC=CC(=C2)C[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C1)C(=O)NC3CCCC3)CCN4CCOCC4)N5CCCC5=O

靶点实验

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实验名称：Antimalarial activity against erythrocytic stage Plasmodium falciparum 3D7 measured a... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL5148564

实验名称：Inhibition of Plasmodium falciparum 20S proteasome beta-5 subunit using Suc-LLVY-AMC ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5148565

实验名称：Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 30 ... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL5148574

实验名称：Efflux ratio of apparent permeability from basolateral to apical side over apical to ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5148570

实验名称：IC50 Determination from US Patent US20240043470: "MACROCYCLIC COMPOUNDS AS PROTEASOME... 来源：BindingDB 靶标：N/A External Id：BindingDB_11823_1

实验名称：Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 1 uM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5148571

实验名称：Metabolic stability in human liver microsomes assessed as intrinsic clearance at 1 uM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5148572

实验名称：Kinetic solubility of compound in PBS at pH 6.8 incubated for 24 hrs by UPLC/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5148573

实验名称：Inhibition of human 20S constitutive proteasome beta-5c subunit using Suc-LLVY-AMC as... 来源：ChEMBL 靶标：Proteasome subunit beta type-5 External Id：CHEMBL5148566

实验名称：Inhibition of human 20S immunoproteasome beta-5i subunit using Ac-ANW-AMC as substrat... 来源：ChEMBL 靶标：Proteasome subunit beta type-8 External Id：CHEMBL5148567

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