4-((2-(2-(2-(2-(4-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

• 常用名: 4-((2-(2-(2-(2-(4-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• 英文名: 4-((2-(2-(2-(2-(4-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• CAS号: 2360561-66-4
• 分子量: 912.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₆H₄₈N₁₂O₉
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4-((2-(2-(2-(2-(4-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

物理化学性质

• 分子式: C₄₆H₄₈N₁₂O₉
• 分子量: 912.9
• InChIKey: DAKOVCJVMZQQAH-XMGIQNEDSA-N
• SMILES: Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCN(C(=O)c2cn(CCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn2)C1

靶点实验

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实验名称：Induction of degradation of BTK in human Ramos cells at 100 nM relative to control 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL5124397

实验名称：Protac activity at CRBN/BTK C481S mutant in human MCL cells assessed as induction of ... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4388620

实验名称：Degradation of ZFN280D in human TMD8 cells by measuring protein level at 111 nM for 6... 来源：ChEMBL 靶标：Zinc finger protein 280D External Id：CHEMBL5342673

实验名称：Degradation of GSTP1 in human TMD8 cells by measuring protein level at 111 nM for 6 h... 来源：ChEMBL 靶标：Eukaryotic peptide chain release factor GTP-binding subunit ERF3A External Id：CHEMBL5342674

实验名称：Protac activity at CRBN/BTK C481S mutant in human MM cells assessed as induction of B... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4388622

实验名称：Degradation of IKZF1 in human TMD8 cells by measuring protein level at 111 nM for 6 h... 来源：ChEMBL 靶标：DNA-binding protein Ikaros External Id：CHEMBL5342671

实验名称：Degradation of IKZF3 in human TMD8 cells by measuring protein level at 111 nM for 6 h... 来源：ChEMBL 靶标：Zinc finger protein Aiolos External Id：CHEMBL5342672

实验名称：Induction of BTK (unknown origin) degradation in Burkitts lymphoma cells at 100 nM re... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL5243527

实验名称：Degradation of FRK in human TMD8 cells by measuring protein level at 111 nM for 6 hrs... 来源：ChEMBL 靶标：Tyrosine-protein kinase FRK External Id：CHEMBL5342665

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