TNIK-IN-6

• 常用名: TNIK-IN-6
• 英文名: TNIK-IN-6
• CAS号: 2375196-40-8
• 分子量: 319.13
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₃H₈BrFN₄
• 熔点: N/A
• 闪点: N/A

TNIK-IN-6用途

TNIK-IN-6 (Compound 9) 是 Traf2 和 Nck 相互作用激酶 (TNIK)的抑制剂,IC50 为 0.93 nM,在神经和精神疾病中发挥重要作用。

TNIK-IN-6名称

• 英文名: TNIK-IN-6

TNIK-IN-6生物活性

• 描述: TNIK-IN-6 (Compound 9) 是 Traf2 和 Nck 相互作用激酶 (TNIK)的抑制剂,IC50 为 0.93 nM,在神经和精神疾病中发挥重要作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Koc-Kan Ho, et al. Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors. Bioorg Med Chem Lett. 2013 Jan 15;23(2):569-73.

  [2]. Jon Read, et al. Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1962-1967.

TNIK-IN-6物理化学性质

• 分子式: C₁₃H₈BrFN₄
• 分子量: 319.13

TNIK-IN-6靶点实验

查看更多实验

实验名称：Inhibition of human 6His-TEV-Avi-MINK1(1 to 328)-GNS expressed in baculovirus-infecte... 来源：ChEMBL 靶标：Misshapen-like kinase 1 External Id：CHEMBL4434085

实验名称：Inhibition of human 6His-TEV-TNIK(1 to 325) expressed in baculovirus-infected sf21 ce... 来源：ChEMBL 靶标：TRAF2 and NCK-interacting protein kinase External Id：CHEMBL4434086

实验名称：Inhibition of human 6His-TEV-SHM-MAP4K4(2 to 328)-GNS expressed in baculovirus-infect... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase kinase 4 External Id：CHEMBL4434087

实验名称：Inhibition of AAK1 (unknown origin) at 0.1 uM relative to control 来源：ChEMBL 靶标：AP2-associated protein kinase 1 External Id：CHEMBL4434092

实验名称：Inhibition of human full length TNIK in HEK293 cells co-transfected with full length ... 来源：ChEMBL 靶标：TRAF2 and NCK-interacting protein kinase External Id：CHEMBL4434082

实验名称：Inhibition of human TNIK in human iPSC derived neuronal progenitor cells assessed as ... 来源：ChEMBL 靶标：TRAF2 and NCK-interacting protein kinase External Id：CHEMBL4434083

实验名称：Inhibition of MAP4K4 (unknown origin) at 0.1 uM relative to control 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase kinase 4 External Id：CHEMBL4434084

实验名称：Inhibition of IRAK3 (unknown origin) at 0.1 uM relative to control 来源：ChEMBL 靶标：Interleukin-1 receptor-associated kinase 3 External Id：CHEMBL4434093

实验名称：Inhibition of MYLK4 (unknown origin) at 0.1 uM relative to control 来源：ChEMBL 靶标：Myosin light chain kinase family member 4 External Id：CHEMBL4434094

实验名称：Inhibition of full length LRRK2 (unknown origin) at 0.1 uM relative to control 来源：ChEMBL 靶标：Leucine-rich repeat serine/threonine-protein kinase 2 External Id：CHEMBL4434095

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