N-{2-[(2S,4S)-4-amino-2-(hydroxymethyl)pyrrolidin-1-yl]-5-fluorophenyl}-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide

• 常用名: N-{2-[(2S,4S)-4-amino-2-(hydroxymethyl)pyrrolidin-1-yl]-5-fluorophenyl}-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide
• 英文名: N-{2-[(2S,4S)-4-amino-2-(hydroxymethyl)pyrrolidin-1-yl]-5-fluorophenyl}-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide
• CAS号: 2375421-82-0
• 分子量: 455.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₃F₂N₅O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-{2-[(2S,4S)-4-amino-2-(hydroxymethyl)pyrrolidin-1-yl]-5-fluorophenyl}-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide

物理化学性质

• 分子式: C₂₃H₂₃F₂N₅O₃
• 分子量: 455.5
• InChIKey: SUBYPZBREZXPCW-GJZGRUSLSA-N
• SMILES: COC1=C(C(=CC=C1)F)C2=NC=CC(=N2)C(=O)NC3=C(C=CC(=C3)F)N4C[C@H](C[C@H]4CO)N

靶点实验

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实验名称：Permeability across apical to basolateral side in human Caco-2 cells incubated for 12... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5225842

实验名称：Inhibition of hERG at 30 uM incubated for 24 hrs by scintillation counter analysis re... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL5225841

实验名称：HPK1 Kinase Binding Assay from US Patent US10800761: "Carboxamide compounds and uses ... 来源：BindingDB 靶标：N/A External Id：BindingDB_9444_1

实验名称：Inhibition of STK4 (unknown origin) incubated for 90 mins in presence of ATP by micro... 来源：ChEMBL 靶标：Serine/threonine-protein kinase 4 External Id：CHEMBL5225838

实验名称：Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by mic... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase kinase 2 External Id：CHEMBL5225837

实验名称：Inhibition of human HPK1 in human whole blood assessed as reduction in SLP76 phosphor... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase kinase 1 External Id：CHEMBL5225840

实验名称：Inhibition of HPK1 in human Jurkat cells assessed as inhibition constant incubated fo... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase kinase 1 External Id：CHEMBL5225830

实验名称：Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by micro... 来源：ChEMBL 靶标：High affinity nerve growth factor receptor External Id：CHEMBL5225832

实验名称：Inhibition of HPK1 in human Jurkat cells assessed as inhibition of SLP76 phosphorylat... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase kinase 1 External Id：CHEMBL5225831

实验名称：HPK1 Kinase Binding Assay from US Patent US11731958: "Carboxamide compounds and uses ... 来源：BindingDB 靶标：N/A External Id：BindingDB_11416_1

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