4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸

• 常用名: 4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸
• 英文名: Eritadenine
• CAS号: 23918-98-1
• 分子量: 253.21
• 密度: 1.92g/cm3
• 沸点: 721.3ºC at 760 mmHg
• 分子式: C₉H₁₁N₅O₄
• 熔点: N/A
• 闪点: 390ºC

用途

Eritadenine (Lentinacin) 是一种 S-腺苷同型半胱氨酸水解酶 (SAHH) 抑制剂,可从香菇的次级代谢产物中获得。Eritadenine 能降低血液胆固醇水平,可用于心血管疾病的研究。

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸名称

• 中文名: 4-(9-腺嘌呤)-D-鞘氨醇-2,3-二羟基丁酸
• 英文名: 4-(9-adenyl)-d-erythro-2,3-dihydroxybutyric acid
• 中文别名: 4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸生物活性

• 描述: Eritadenine (Lentinacin) 是一种 S-腺苷同型半胱氨酸水解酶 (SAHH) 抑制剂,可从香菇的次级代谢产物中获得。Eritadenine 能降低血液胆固醇水平,可用于心血管疾病的研究。
• 相关类别:
  研究领域 >> 心血管疾病
• 靶点实验:

  SAHH[1][2].

• 参考文献:

  [1]. Yamada T, et al. Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents. Biochem Pharmacol. 2007 Apr 1;73(7):981-9.

  [2]. Morales D, et al. Effect of traditional and modern culinary processing, bioaccessibility, biosafety and bioavailability of eritadenine, a hypocholesterolemic compound from edible mushrooms. Food Funct. 2018 Dec 13;9(12):6360-6368.

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸物理化学性质

• 密度: 1.92g/cm3
• 沸点: 721.3ºC at 760 mmHg
• 分子式: C₉H₁₁N₅O₄
• 分子量: 253.21
• 闪点: 390ºC
• 精确质量: 253.08100
• PSA: 147.38000
• InChIKey: LIEMBEWXEZJEEZ-INEUFUBQSA-N
• SMILES: Nc1ncnc2c1ncn2CC(O)C(O)C(=O)O
• 蒸汽压: 7.75E-22mmHg at 25°C
• 折射率: 1.823
• 储存条件: 2-8°C

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸毒性和生态

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸安全信息

• 海关编码: 2933990090

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸靶点实验

查看更多实验

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Compound was evaluated for the inhibition of human FECH at 10uM 来源：ChEMBL 靶标：Ferrochelatase, mitochondrial External Id：CHEMBL3987222

实验名称：Compound was evaluated for the inhibition of human HMBS at 100uM 来源：ChEMBL 靶标：Porphobilinogen deaminase External Id：CHEMBL3987223

实验名称：AntiCryptosporidium parvum activity Compounds added 3h after t0, IC 50 (uM) 来源：ChEMBL 靶标：Cryptosporidium parvum External Id：CHEMBL3832793

实验名称：Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MI... 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL4296188

实验名称：Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL4296187

实验名称：Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 (CO-ADD:FG_002); ... 来源：ChEMBL 靶标：Cryptococcus neoformans External Id：CHEMBL4296190

共14条，当前第1页，共2页

1

2

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸英文别名

• Lentysine
• d-4-(6-amino-9h-purin-9-yl)-4-deoxyerythronicacid
• d-erythronicaci
• lentinacin
• 2(R),3(R)-dihydroxy-4-(9-adenyl)butyric acid
• D-eritadenine acid
• 4-(6-AMinopurin-9-yl)-4-deoxy-D-erythronic Acid
• 4-(6-amino-purin-9-yl)-2,3-dihydroxy-butyric acid
• 4-(6-AMino-9H-purin-9-yl)-4-deoxy-D-erythronic Acid
• D-Eritadenine
• AA-307
• eritadenine