阿法多龙醋酸酯

• 常用名: 阿法多龙醋酸酯
• 英文名: 3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate
• CAS号: 23930-37-2
• 分子量: 390.51300
• 密度: 1.164g/cm3
• 沸点: 523.6ºC at 760mmHg
• 分子式: C₂₃H₃₄O₅
• 熔点: N/A
• 闪点: 175.1ºC

阿法多龙醋酸酯用途

醋酸阿法龙(醋酸阿法隆)是一种类固醇麻醉剂,具有抗伤害作用[1]。

阿法多龙醋酸酯名称

• 中文名: 阿法多龙醋酸酯
• 英文名: (3α,5α)-3-Hydroxy-11,20-dioxopregnan-21-yl acetate

阿法多龙醋酸酯生物活性

• 描述: 醋酸阿法龙(醋酸阿法隆)是一种类固醇麻醉剂,具有抗伤害作用[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: 当与阿法沙龙联合使用时,醋酸阿法沙隆(用3∶1的阿法沙酮和醋酸阿法龙混合物麻醉；i.m.)阻断雌激素刺激的黄体生成素(LH)激增并损害雌性大鼠的搏动分泌[2]。醋酸阿法龙(14 mL/kg；腹腔注射；单剂量)降低去势大鼠的LH血清浓度[3]。动物模型：近交Wistar衍生集落雌性大鼠(肌肉注射20µg/100g苯甲酸雌二醇)[2]剂量：用阿法沙龙和醋酸阿法沙隆的3:1混合物进行麻醉：i.m.结果：阻断雌激素刺激的LH激增并损害搏动分泌。动物模型：雄性Sprague-Dawley大鼠(兰花切除；90-120天龄,体重300-350 g)[3]剂量：14 mL/kg给药：i.p。；单剂量结果：血清LH浓度降低。

阿法多龙醋酸酯物理化学性质

• 密度: 1.164g/cm3
• 沸点: 523.6ºC at 760mmHg
• 分子式: C₂₃H₃₄O₅
• 分子量: 390.51300
• 闪点: 175.1ºC
• 精确质量: 390.24100
• PSA: 80.67000
• LogP: 3.31740
• InChIKey: QRJOQYLXZPQQMX-FWROMSNXSA-N
• SMILES: CC(=O)OCC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3C(=O)CC12C
• 蒸汽压: 3.75E-13mmHg at 25°C
• 折射率: 1.53

阿法多龙醋酸酯靶点实验

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实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：GPR151 activator identification: cell-based high-throughput counter-screen assay 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Glucose-dependent insulinotropic receptor; AltName: Full=G-protein coupled receptor 119 External Id：GPR119_PHUNTER_AG_LUMI_1536_3X%ACT CSRUN1

实验名称：EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Rea... 来源：Broad Institute 靶标：histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens] External Id：2125-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：GPR151 activator identification: cell-based high-throughput confirmation assay 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_3X%ACT CRUN1

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

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阿法多龙醋酸酯英文别名

• 2-phenoxyethyl 4-(2,3-dimethoxyphenyl)-7-(4-methoxyphenyl)-2-methyl-5-oxo-1,4,6,7,8-pentahydroquinoline-3-carboxylate
• 2-phenoxyethyl 4-(2,3-dimethoxyphenyl)-7-(4-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
• endo-Bicyclo<3.3.1>nonan-3-ol
• exo-Bicyclo<3.3.1>nonanol-3
• exo-Bicyclo<3.3.1>nonan-3-ol