HDAC-IN-38

• 常用名: HDAC-IN-38
• 英文名: HDAC-IN-38
• CAS号: 2408123-36-2
• 分子量: 461.98
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₈ClN₃O₂
• 熔点: N/A
• 闪点: N/A

HDAC-IN-38用途

HDAC-IN-38(化合物13)是一种有效的HDAC抑制剂。HDAC-IN-38对HDAC1、2、3、5、6和8表现出类似的微摩尔抑制活性。HDAC-IN-38增加脑血流量(CBF),减轻认知障碍,改善海马萎缩。HDAC-IN-38还可增加组蛋白乙酰化水平(H3K14或H4K5)[1]。

HDAC-IN-38名称

• 英文名: HDAC-IN-38

HDAC-IN-38生物活性

• 描述: HDAC-IN-38(化合物13)是一种有效的HDAC抑制剂。HDAC-IN-38对HDAC1、2、3、5、6和8表现出类似的微摩尔抑制活性。HDAC-IN-38增加脑血流量(CBF),减轻认知障碍,改善海马萎缩。HDAC-IN-38还可增加组蛋白乙酰化水平(H3K14或H4K5)[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> HDAC
  研究领域 >> 神经疾病
  信号通路 >> 表观遗传学 >> HDAC
• 靶点实验:

  HDAC8:0.533 μM (IC50)

  HDAC6:1.27 μM (IC50)

  HDAC3:2.86 μM (IC50)

  HDAC1:3.82 μM (IC50)

  HDAC5:6.27 μM (IC50)

  HDAC2:6.62 μM (IC50)

• 参考文献:

  [1]. Kaur N, et al. Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. Eur J Med Chem. 2020 Feb 1;187:111915.

HDAC-IN-38物理化学性质

• 分子式: C₂₇H₂₈ClN₃O₂
• 分子量: 461.98

HDAC-IN-38靶点实验

查看更多实验

实验名称：Aqueous solubility of compound in ethanol incubated at 37 degree C by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4604171

实验名称：Aqueous solubility of compound in water incubated at 37 degree C by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4604170

实验名称：Neuroprotective activity against OGD-induced hypoxic injury in human SH-SY5Y cells as... 来源：ChEMBL 靶标：SH-SY5Y External Id：CHEMBL4604172

实验名称：Anti-vascular cognitive impairment activity against bilateral common carotid artery o... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4604176

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po measured up to 24 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL4604163

实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv measured ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4604162

实验名称：Half life in Sprague-Dawley rat at 10 mg/kg, po measured up to 24 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL4604164

实验名称：Oral bioavailability in Sprague-Dawley rat at 10 mg/kg measured up to 24 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL4604167

实验名称：Tmax in Sprague-Dawley rat at 10 mg/kg, po measured up to 24 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL4604166

实验名称：Microsomal stability in human liver microsomes assessed as parent compound remaining ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4604169

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