3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzoic acid

• 常用名: 3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzoic acid
• 英文名: 3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzoic acid
• CAS号: 243982-49-2
• 分子量: 311.64
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁H₉ClF₃NO₄
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]benzoic acid

物理化学性质

• 分子式: C₁₁H₉ClF₃NO₄
• 分子量: 311.64
• InChIKey: CFKHTEWRARJPEJ-SNVBAGLBSA-N
• SMILES: C[C@@](C(=O)NC1=C(C=C(C=C1)C(=O)O)Cl)(C(F)(F)F)O

靶点实验

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实验名称：In vivo inhibition of pyruvate dehydrogenase kinase, reduced lactate level in normal ... 来源：ChEMBL 靶标：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial External Id：CHEMBL767700

实验名称：In vitro inhibitory activity against Pyruvate dehydrogenase kinase by primary enzymat... 来源：ChEMBL 靶标：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial External Id：CHEMBL767697

实验名称：The area under the curve of compound was measured at the dose of 100 umol/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL622846

实验名称：The biological half life the compound was measured at the dose of 100 umol/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL628608

实验名称：In vivo percent of control lactate in 24 hr fasted rats at 100 umol/kg oral dose 来源：ChEMBL 靶标：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial External Id：CHEMBL883580

实验名称：The time to reach maximum concentration of compound was measured at the dose of 100 u... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL622459

实验名称：In vivo inhibion of pyruvate dehydrogenase kinase, increased oxidation of lactate 来源：ChEMBL 靶标：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial External Id：CHEMBL767695

实验名称：In vivo percent of control lactate in 24 hr fasted rats at 30 uM/kg oral dose 来源：ChEMBL 靶标：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial External Id：CHEMBL775107

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