D-荧光素

• 常用名: D-荧光素
• 英文名: D-Luciferin 6′-methyl ether
• CAS号: 24404-90-8
• 分子量: 294.34900
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₀N₂O₃S₂
• 熔点: N/A
• 闪点: N/A

D-荧光素用途

D-荧光素6′-甲基醚(6′-甲氧基荧光素；化合物19a)是一种来自北美萤火虫Pypyluc(PpyLuc)抑制剂的有效荧光素酶,IC50为0.1µM。D-荧光素6′-甲基醚是一种D-荧光素类似物,在PpyLuc活性位点的ATP-和荧光素结合位点显示非特异性相互作用[1]。

D-荧光素名称

• 中文名: D-荧光素
• 英文名: (S)-2-(6-methoxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

D-荧光素生物活性

• 描述: D-荧光素6′-甲基醚(6′-甲氧基荧光素；化合物19a)是一种来自北美萤火虫Pypyluc(PpyLuc)抑制剂的有效荧光素酶,IC50为0.1µM。D-荧光素6′-甲基醚是一种D-荧光素类似物,在PpyLuc活性位点的ATP-和荧光素结合位点显示非特异性相互作用[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Giuseppe Meroni, et al. D-Luciferin, derivatives and analogues: synthesis and in vitro/in vivo luciferase-catalyzed bioluminescent activity. Volume 2009, Issue 1, Reviews and Accounts, pp. 265-288

D-荧光素物理化学性质

• 分子式: C₁₂H₁₀N₂O₃S₂
• 分子量: 294.34900
• 精确质量: 294.01300
• PSA: 125.32000
• LogP: 1.68710
• InChIKey: ZTQKCGHSTKIWFW-MRVPVSSYSA-N
• SMILES: COc1ccc2nc(C3=NC(C(=O)O)CS3)sc2c1
• 储存条件: -20°C，密封，干燥

D-荧光素靶点实验

查看更多实验

实验名称：Inhibition of NUAK1 (unknown origin) assessed as remaining activity at 100 uM by radi... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL3427814

实验名称：Inhibition of MINK1 (unknown origin) assessed as remaining activity at 100 uM by radi... 来源：ChEMBL 靶标：Misshapen-like kinase 1 External Id：CHEMBL3427815

实验名称：Inhibition of N-terminal His-tagged CDK2-cyclin A (unknown origin) assessed as remain... 来源：ChEMBL 靶标：Cyclin-A2 External Id：CHEMBL3427812

实验名称：Inhibition of GSK-3beta (unknown origin) assessed as remaining activity at 100 uM by ... 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL3427813

实验名称：Inhibition of BRSK2 (unknown origin) assessed as remaining activity at 100 uM by radi... 来源：ChEMBL 靶标：Serine/threonine-protein kinase BRSK2 External Id：CHEMBL3427818

实验名称：Inhibition of GCK (unknown origin) assessed as remaining activity at 100 uM by radioa... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase kinase 2 External Id：CHEMBL3427819

实验名称：Inhibition of RSK2 (unknown origin) assessed as remaining activity at 100 uM by radio... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-3 External Id：CHEMBL3427816

实验名称：Inhibition of CAMK1 (unknown origin) assessed as remaining activity at 100 uM by radi... 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type 1 External Id：CHEMBL3427817

实验名称：Inhibition of MLK3 (unknown origin) assessed as remaining activity at 100 uM by radio... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 11 External Id：CHEMBL3427822

实验名称：Inhibition of PIM2 (unknown origin) assessed as remaining activity at 100 uM by radio... 来源：ChEMBL 靶标：Serine/threonine-protein kinase pim-2 External Id：CHEMBL3427823

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D-荧光素英文别名

• LucME
• D-methoxyluc
• lucifern 6'-methyl ether