hPL-IN-2

• 常用名: hPL-IN-2
• 英文名: hPL-IN-2
• CAS号: 24900-61-6
• 分子量: 443.11
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₁Cl₄NO₃
• 熔点: N/A
• 闪点: N/A

hPL-IN-2用途

hPL-IN-2 (compound 2u) 是胰脂肪酶 (Pancreatic lipase) 的强效、可逆、和非竞争性抑制剂 (IC50: 1.63 μM)，可用于抗肥胖的研究。靶点： IC50: 1.63 μM (Pancreatic lipase, PL); Ki：1.7 μM (human PL)。参考文献： 1. Zhao Y, et al. Design, synthesis and biological evaluation of salicylanilides as novel allosteric inhibitors of human pancreatic lipase. Bioorg Med Chem. 2023 Aug 15;91:117413.

hPL-IN-2名称

• 英文名: hPL-IN-2

hPL-IN-2生物活性

• 描述: hPL-IN-2 (compound 2u) 是胰脂肪酶 (Pancreatic lipase) 的强效、可逆、和非竞争性抑制剂 (IC50: 1.63 μM),可用于抗肥胖的研究。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 靶点实验:

  IC50: 1.63 μM (Pancreatic lipase, PL); Ki：1.7 μM (human PL)[1]

• 参考文献:

  [1]. Zhao Y, et al. Design, synthesis and biological evaluation of salicylanilides as novel allosteric inhibitors of human pancreatic lipase. Bioorg Med Chem. 2023 Aug 15;91:117413..

hPL-IN-2物理化学性质

• 分子式: C₁₉H₁₁Cl₄NO₃
• 分子量: 443.11
• InChIKey: HPIKHGXRCDJEKT-UHFFFAOYSA-N
• SMILES: O=C(Nc1ccc(Oc2ccc(Cl)cc2)c(Cl)c1)c1cc(Cl)cc(Cl)c1O
• 储存条件: -20℃

hPL-IN-2靶点实验

查看更多实验

实验名称：Binding affinity to human Pancreatic lipase assessed as quenching constant by fluores... 来源：ChEMBL 靶标：Pancreatic triacylglycerol lipase External Id：CHEMBL5328240

实验名称：Binding affinity to human Pancreatic lipase assessed as Stem-Volmer quenching constan... 来源：ChEMBL 靶标：Pancreatic triacylglycerol lipase External Id：CHEMBL5328239

实验名称：Inhibition of SPAK (unknown origin) by ELISA 来源：ChEMBL 靶标：STE20/SPS1-related proline-alanine-rich protein kinase External Id：CHEMBL4727716

实验名称：Antimicrobial activity against Clostridioides difficile CD10463 incubated for 20 to 2... 来源：ChEMBL 靶标：Clostridioides difficile External Id：CHEMBL4612662

实验名称：Negative allosteric modulator activity at human Pancreatic lipase using DDAO-ol as fl... 来源：ChEMBL 靶标：Pancreatic triacylglycerol lipase External Id：CHEMBL5328237

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