KT-531

• 常用名: KT-531
• 英文名: KT-531
• CAS号: 2490284-18-7
• 分子量: 418.363
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₄F₄N₂O₄S
• 熔点: N/A
• 闪点: N/A

KT-531用途

KT-531(KT531)是一种有效的选择性HDAC6抑制剂,IC50为8.5 nM,选择性为39倍。

KT-531名称

• 英文名: KT-531

KT-531生物活性

• 描述: KT-531(KT531)是一种有效的选择性HDAC6抑制剂,IC50为8.5 nM,选择性为39倍。
• 参考文献: 1. Krimo Toutah, et al. J Med Chem. 2021 Jun 24;64(12):8486-8509.

KT-531物理化学性质

• 分子式: C₁₇H₁₄F₄N₂O₄S
• 分子量: 418.363
• InChIKey: HYEWQOQZANKATO-UHFFFAOYSA-N
• SMILES: O=C(NO)c1ccc(CN(C2CC2)S(=O)(=O)c2cc(F)c(F)c(F)c2F)cc1

KT-531靶点实验

查看更多实验

实验名称：Induction of apoptosis in human MV4-11 cells assessed as late apoptotic cells at 1 uM... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5132060

实验名称：Induction of apoptosis in human MV4-11 cells at 0.5 uM assessed as increase in cleave... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5132061

实验名称：Induction of apoptosis in human MV4-11 cells at 0.5 uM assessed as increase in cleave... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5132062

实验名称：Induction of apoptosis in human MV4-11 cells at 5 uM assessed as reduction in cleaved... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5132063

实验名称：Intrinsic clearance in mouse hepatocytes assessed per 10^6 cells upto 120 mins by LC/... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5132056

实验名称：Effective permeability of compound at pH 7.4 measured after 16 hrs by PAMPA based LC/... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5132057

实验名称：Stability in mouse plasma assessed as half life at 1 uM measured upto 60 mins by LC/M... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5132058

实验名称：Half life in mouse hepatocytes measured upto 120 mins by LC/MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5132055

实验名称：Inhibition of HDAC6 in human HeLa cells assessed as increase in acetylated alpha tubu... 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL5132048

实验名称：Inhibition of HDAC1 in human HeLa cells assessed as acetylation of histone H3 incubat... 来源：ChEMBL 靶标：Histone deacetylase 1 External Id：CHEMBL5132049

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