2’-Deoxy-2’-fluoro-b-D-arabinocytidine hydrochloride

• 常用名: 2’-Deoxy-2’-fluoro-b-D-arabinocytidine hydrochloride
• 英文名: 2’-Deoxy-2’-fluoro-b-D-arabinocytidine hydrochloride
• CAS号: 25183-22-6
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: N/A
• 熔点: N/A
• 闪点: N/A

用途

2'-脱氧-2'-氟-b-D-阿拉伯胞苷(盐酸盐)是胞苷核苷类似物。胞苷类似物具有抑制DNA甲基转移酶的机制(如Zebularine,HY-13420),并具有潜在的抗代谢和抗肿瘤活性[1]。

名称

• 英文名: 2'-Deoxy-2'-fluoro-beta-D-arabinocytidine hydrochloride

生物活性

• 描述: 2'-脱氧-2'-氟-b-D-阿拉伯胞苷(盐酸盐)是胞苷核苷类似物。胞苷类似物具有抑制DNA甲基转移酶的机制(如Zebularine,HY-13420),并具有潜在的抗代谢和抗肿瘤活性[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.

物理化学性质

• InChIKey: AOHUNXMLBSSCKF-NKCNMFRMSA-N
• SMILES: Cl.Nc1ccn(C2OC(CO)C(O)C2F)c(=O)n1

靶点实验

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