hMAO-B-IN-3

• 常用名: hMAO-B-IN-3
• 英文名: hMAO-B-IN-3
• CAS号: 2581113-51-9
• 分子量: 333.34
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₅NO₄
• 熔点: N/A
• 闪点: N/A

hMAO-B-IN-3用途

hMAO-B-IN-3(化合物15)是hMAO-B的有效抑制剂,IC50为47.4 nM。hMAO-B-IN-3具有良好的类药物特性和广阔的安全窗口。因此,hMAO-B-IN-3是铅优化和多靶点定向配体开发的合适候选者【1】。

hMAO-B-IN-3名称

• 英文名: hMAO-B-IN-3

hMAO-B-IN-3生物活性

• 描述: hMAO-B-IN-3(化合物15)是hMAO-B的有效抑制剂,IC50为47.4 nM。hMAO-B-IN-3具有良好的类药物特性和广阔的安全窗口。因此,hMAO-B-IN-3是铅优化和多靶点定向配体开发的合适候选者【1】。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Chavarria D, et al. Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies. Eur J Med Chem. 2020 Jan 1;185:111770.

hMAO-B-IN-3物理化学性质

• 分子式: C₂₀H₁₅NO₄
• 分子量: 333.34

hMAO-B-IN-3靶点实验

查看更多实验

实验名称：Stability of compound in DMSO-d6 and D2O (7:3) measured after 30 mins to 1 hr in pres... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4316083

实验名称：Inhibition of P-gp in human Caco2 cells assessed as decrease in Rho123 efflux by meas... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL4316082

实验名称：Retention time of compound at pH 7.4 by LC-UV analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4316081

实验名称：Chromatographic hydrophobicity index, log D of compound at 250 uM at pH 7.4 by HPLC a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4316080

实验名称：Chromatographic hydrophobicity index of compound at 250 uM at pH 7.4 by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4316079

实验名称：Cytotoxicity against human Caco2 cells assessed as cellular metabolic activity by mea... 来源：ChEMBL 靶标：Caco-2 External Id：CHEMBL4316078

实验名称：Competitive inhibition of human microsomal MAO-B expressed in baculovirus infected BT... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL4316092

实验名称：Reversible inhibition of human microsomal MAO-B expressed in baculovirus infected BTI... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL4316090

实验名称：Cytotoxicity against human SH-SY5Y cells assessed as cellular metabolic activity by m... 来源：ChEMBL 靶标：SH-SY5Y External Id：CHEMBL4316086

实验名称：Cytotoxicity against human SH-SY5Y cells assessed as lysosomal activity by measuring ... 来源：ChEMBL 靶标：SH-SY5Y External Id：CHEMBL4316085

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