(2S,4R)-N-((S)-3-(4-(4-((trans-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)phenyl)piperazin-1-yl)-3-oxo-1-phenylpropyl)-4-hydroxy-1-((R)-3-methyl-2-(3-methylisoxazol-5-yl)butanoyl)pyrrolidine-2-carboxamide

• 常用名: (2S,4R)-N-((S)-3-(4-(4-((trans-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)phenyl)piperazin-1-yl)-3-oxo-1-phenylpropyl)-4-hydroxy-1-((R)-3-methyl-2-(3-methylisoxazol-5-yl)butanoyl)pyrrolidine-2-carboxamide
• 英文名: (2S,4R)-N-((S)-3-(4-(4-((trans-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)phenyl)piperazin-1-yl)-3-oxo-1-phenylpropyl)-4-hydroxy-1-((R)-3-methyl-2-(3-methylisoxazol-5-yl)butanoyl)pyrrolidine-2-carboxamide
• CAS号: 2581825-66-1
• 分子量: 892.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₉H₅₈ClN₇O₇
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (2S,4R)-N-((S)-3-(4-(4-((trans-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)phenyl)piperazin-1-yl)-3-oxo-1-phenylpropyl)-4-hydroxy-1-((R)-3-methyl-2-(3-methylisoxazol-5-yl)butanoyl)pyrrolidine-2-carboxamide

物理化学性质

• 分子式: C₄₉H₅₈ClN₇O₇
• 分子量: 892.5
• InChIKey: PCESUBZRKODSDM-HLSUSKJASA-N
• SMILES: Cc1cc(C(C(=O)N2CC(O)CC2C(=O)NC(CC(=O)N2CCN(c3ccc(C(=O)NC4C(C)(C)C(Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)c2ccccc2)C(C)C)on1

靶点实验

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实验名称：Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as induction... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL4324993

实验名称：Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as induction... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL4324992

实验名称：Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as induction... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL4324991

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