4-(7-((1H-Imidazol-1-YL)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-YL)-1-oxo-3,4-dihydroisoquinolin-2(1H)-YL)-6-ethyl-N-methylquinoline-8-carboxamide

• 常用名: 4-(7-((1H-Imidazol-1-YL)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-YL)-1-oxo-3,4-dihydroisoquinolin-2(1H)-YL)-6-ethyl-N-methylquinoline-8-carboxamide
• 英文名: 4-(7-((1H-Imidazol-1-YL)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-YL)-1-oxo-3,4-dihydroisoquinolin-2(1H)-YL)-6-ethyl-N-methylquinoline-8-carboxamide
• CAS号: 2642333-22-8
• 分子量: 587.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₁H₂₈F₃N₇O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4-(7-((1H-Imidazol-1-YL)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-YL)-1-oxo-3,4-dihydroisoquinolin-2(1H)-YL)-6-ethyl-N-methylquinoline-8-carboxamide

物理化学性质

• 分子式: C₃₁H₂₈F₃N₇O₂
• 分子量: 587.6
• InChIKey: SHGMSJNVTCKQHS-UHFFFAOYSA-N
• SMILES: CCC1=CC2=C(C=CN=C2C(=C1)C(=O)NC)N3CCC4=C(C=C(C=C4C3=O)CN5C=CN=C5)C6=CN(N=C6C(F)(F)F)C

靶点实验

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实验名称：Protein binding in mouse whole blood at 1 uM incubated for 4 hrs by LC-MS/MS based ra... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5379284

实验名称：Antiproliferative activity against human K562 cells assessed as growth inhibition inc... 来源：ChEMBL 靶标：K562 External Id：CHEMBL5379278

实验名称：Selectivity ratio of GI50 for human K562 cells to GI50 for human MV4-11 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL5379279

实验名称：Antiproliferative activity against human MV4-11 cells assessed as growth inhibition i... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5379276

实验名称：Antiproliferative activity against human MOLM-13 cells assessed as growth inhibition ... 来源：ChEMBL 靶标：MOLM-13 External Id：CHEMBL5379277

实验名称：Inhibition of 6His-SUMO tagged human WDR5 (22 to 334 residues) expressed in Escherich... 来源：ChEMBL 靶标：WD repeat-containing protein 5 External Id：CHEMBL5379275

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