N-[4-[2-[3-(3,5-dimethoxyphenyl)-2-oxo-7-[2-(prop-2-enoylamino)anilino]-4H-pyrimido[4,5-d]pyrimidin-1-yl]ethyl]phenyl]prop-2-enamide

• 常用名: N-[4-[2-[3-(3,5-dimethoxyphenyl)-2-oxo-7-[2-(prop-2-enoylamino)anilino]-4H-pyrimido[4,5-d]pyrimidin-1-yl]ethyl]phenyl]prop-2-enamide
• 英文名: N-[4-[2-[3-(3,5-dimethoxyphenyl)-2-oxo-7-[2-(prop-2-enoylamino)anilino]-4H-pyrimido[4,5-d]pyrimidin-1-yl]ethyl]phenyl]prop-2-enamide
• CAS号: 2727083-99-8
• 分子量: 619.7
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₃₃N₇O₅
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[4-[2-[3-(3,5-dimethoxyphenyl)-2-oxo-7-[2-(prop-2-enoylamino)anilino]-4H-pyrimido[4,5-d]pyrimidin-1-yl]ethyl]phenyl]prop-2-enamide

物理化学性质

• 分子式: C₃₄H₃₃N₇O₅
• 分子量: 619.7
• InChIKey: NOZQNRBLSPCZJQ-UHFFFAOYSA-N
• SMILES: COC1=CC(=CC(=C1)N2CC3=CN=C(N=C3N(C2=O)CCC4=CC=C(C=C4)NC(=O)C=C)NC5=CC=CC=C5NC(=O)C=C)OC

靶点实验

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实验名称：Selectivity ratio of IC50 for human FGFR4 C477A/C552A double mutant to IC50 for human... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5508625

实验名称：Selectivity ratio of IC50 for human FGFR4 C552A mutant to IC50 for human FGFR4 来源：ChEMBL 靶标：N/A External Id：CHEMBL5508624

实验名称：Selectivity ratio of IC50 for human FGFR4 C477A mutant to IC50 for human FGFR4 来源：ChEMBL 靶标：N/A External Id：CHEMBL5508623

实验名称：Inhibition of FGFR4 (unknown origin) at 1 uM by HTRF method relative to control 来源：ChEMBL 靶标：Fibroblast growth factor receptor 4 External Id：CHEMBL5508647

实验名称：Inhibition of FGFR3 (unknown origin) at 1 uM by HTRF method relative to control 来源：ChEMBL 靶标：Fibroblast growth factor receptor 3 External Id：CHEMBL5508646

实验名称：Inhibition of FGFR2 (unknown origin) at 1 uM by HTRF method relative to control 来源：ChEMBL 靶标：Fibroblast growth factor receptor 2 External Id：CHEMBL5508645

实验名称：Inhibition of FGFR1 (unknown origin) at 1 uM by HTRF method relative to control 来源：ChEMBL 靶标：Fibroblast growth factor receptor 1 External Id：CHEMBL5508644

实验名称：Metabolic stability in rat liver microsomes assessed as half life at 1 uM preincubate... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5508643

实验名称：Inhibition of FGFR4 in human MDA-MB-231 cells assessed as reduction in AKT phosphoryl... 来源：ChEMBL 靶标：Fibroblast growth factor receptor 4 External Id：CHEMBL5508642

实验名称：Inhibition of FGFR4 in human MDA-MB-231 cells assessed as reduction in MAPK phosphory... 来源：ChEMBL 靶标：Fibroblast growth factor receptor 4 External Id：CHEMBL5508641

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