MS934

• 常用名: MS934
• 英文名: MS934
• CAS号: 2756323-15-4
• 分子量: 1104.127
• 密度: N/A
• 沸点: N/A
• 分子式: C₅₂H₆₉F₃In₇O₆S
• 熔点: N/A
• 闪点: N/A

MS934用途

MS934(MS-934)是一种VHL招募MEK1/2降解剂(PROTAC),HT29 DC50为18/9 nM,分别用于MEK1/2降解。在HT-29和SK-MEL-28细胞中,MS934对HT29细胞具有抗增殖作用,GI50为23 nM,降解MEK1和MEK2,并以浓度依赖性方式抑制pMEK和pERK。

MS934名称

• 英文名: MS934

MS934生物活性

• 描述: MS934(MS-934)是一种VHL招募MEK1/2降解剂(PROTAC),HT29 DC50为18/9 nM,分别用于MEK1/2降解。在HT-29和SK-MEL-28细胞中,MS934对HT29细胞具有抗增殖作用,GI50为23 nM,降解MEK1和MEK2,并以浓度依赖性方式抑制pMEK和pERK。
• 参考文献: 1. Jianping Hu, et al. J Med Chem. 2020 Dec 24;63(24):15883-15905.

MS934物理化学性质

• 分子式: C₅₂H₆₉F₃In₇O₆S
• 分子量: 1104.127
• InChIKey: DYLGPTDXXUWFMK-ARFQKLFXSA-N
• SMILES: Cc1ncsc1-c1ccc(C(C)NC(=O)C2CC(O)CN2C(=O)C(NC(=O)CCCCCCCCCCCNCCCCONC(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C(C)(C)C)cc1

MS934靶点实验

查看更多实验

实验名称：Inhibition of MEK1/2 phosphorylation in human SU-DHL-1 cells at 0.3 to 3 uM and incub... 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 2 External Id：CHEMBL4712286

实验名称：Protac activity at VHL/MEK2 in human HT-29 cells assessed as time for induction of ME... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL4712222

实验名称：Inhibition of ERK phosphorylation in human HT-29 cells assessed as time for reduction... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4712223

实验名称：Inhibition of MEK1/2 phosphorylation in human NCI-H3122 cells at 0.3 to 3 uM and incu... 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 2 External Id：CHEMBL4712287

实验名称：Protac activity at VHL/MEK1/2 in human NCI-H3122 cells assessed as induction of MEK1/... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL4712284

实验名称：Protac activity at VHL/MEK1/2 in human SU-DHL-1 cells assessed as induction of MEK1/2... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL4712285

实验名称：Protac activity at VHL/MEK1 in human HT-29 cells assessed as time for induction of ME... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL4712221

实验名称：Protac activity at VHL/MEK2 in human HT-29 cells assessed as time for maximum inducti... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL4712226

实验名称：Inhibition of ERK phosphorylation in human HT-29 cells assessed as time for maximum r... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4712227

实验名称：Inhibition of ERK phosphorylation in human SU-DHL-1 cells at 0.3 to 3 uM and incubate... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4712288

共44条，当前第1页，共5页

1

2

3

4

5