METTL3-IN-3

• 常用名: METTL3-IN-3
• 英文名: METTL3-IN-3
• CAS号: 2767003-71-2
• 分子量: 555.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₈BrFN₆O₂
• 熔点: N/A
• 闪点: N/A

METTL3-IN-3用途

METTL3-IN-3(化合物11)是一种多杂环化合物,用作METTL3抑制剂[1]。

METTL3-IN-3名称

• 英文名: METTL3-IN-3

METTL3-IN-3生物活性

• 描述: METTL3-IN-3(化合物11)是一种多杂环化合物,用作METTL3抑制剂[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 靶点实验:

  METTL3[1]

• 体外研究: METTL3即甲基转移酶样 3.是 第6页-甲基腺苷 (m6A)唯一的催化亚基。METTL3标准参与真核 mRNA表达中内部腺苷残基的转录后甲基化,形成 m6A中米6A是最丰富的 mRNA表达修饰,因此 METTL3标准在多种癌症类型中发挥关键作用,或依赖于或不依赖于其 m6A RNA甲基转移酶活性[2]。
• 参考文献:

  [1]. Blackaby WP, et al. Preparation of polyheterocyclic compounds as METTL3 inhibitors: World Intellectual Property Organization, WO2021111124[P]. 2021-06-10.

  [2]. Zeng C, et al. Roles of METTL3 in cancer: mechanisms and therapeutic targeting. J Hematol Oncol. 2020 Aug 27;13(1):117.

METTL3-IN-3物理化学性质

• 分子式: C₂₆H₂₈BrFN₆O₂
• 分子量: 555.44

METTL3-IN-3靶点实验

查看更多实验

实验名称：Antiproliferative activity against human Kasumi 1 cells assessed as inhibition of cel... 来源：ChEMBL 靶标：Kasumi 1 External Id：CHEMBL5339854

实验名称：Antiproliferative activity against human Caov-3 cells incubated for 120 hrs by CellTi... 来源：ChEMBL 靶标：Caov-3 cell line External Id：CHEMBL5393618

实验名称：Antiproliferative activity against human Caov-3 cell line assessed as inhibition of c... 来源：ChEMBL 靶标：Caov-3 cell line External Id：CHEMBL5339853

实验名称：Antiproliferative activity against human Kasumi 1 cells incubated for 120 hrs by Cell... 来源：ChEMBL 靶标：Kasumi 1 External Id：CHEMBL5393617

实验名称：Inhibition of full length His-tagged METTL3 (unknown origin) co-expressed with full l... 来源：ChEMBL 靶标：N6-adenosine-methyltransferase catalytic subunit External Id：CHEMBL5393616

实验名称：Inhibition of full-length His-tagged METTL3/full length FLAG-tagged METTL14 (unknown ... 来源：ChEMBL 靶标：N6-adenosine-methyltransferase non-catalytic subunit External Id：CHEMBL5339817

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