STOML3 inhibitor OB-1

• 常用名: STOML3 inhibitor OB-1
• 英文名: OB-1
• CAS号: 300803-69-4
• 分子量: 407.376
• 密度: 1.4±0.1 g/cm3
• 沸点: 628.5±55.0 °C at 760 mmHg
• 分子式: C₂₁H₁₇N₃O₆
• 熔点: N/A
• 闪点: 333.9±31.5 °C

STOML3 inhibitor OB-1用途

一种小分子的STOML3寡聚化抑制剂,可逆转体内病理性机械超敏反应；有效抑制stomatin,STOML1和STOML2在2μM时的自缔合,但不能抑制podocin；可逆地降低感觉神经元中机械门控电流的敏感性并沉默机械感受器体内；还可逆地减弱正常小鼠的精细触觉感知,逆转病理性机械超敏反应。

STOML3 inhibitor OB-1名称

• 英文名: Ethyl 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-1-benzofuran-3-carboxylate

STOML3 inhibitor OB-1生物活性

• 描述: 一种小分子的STOML3寡聚化抑制剂,可逆转体内病理性机械超敏反应；有效抑制stomatin,STOML1和STOML2在2μM时的自缔合,但不能抑制podocin；可逆地降低感觉神经元中机械门控电流的敏感性并沉默机械感受器体内；还可逆地减弱正常小鼠的精细触觉感知,逆转病理性机械超敏反应。
• 参考文献: References 1. Wetzel C, et al. Nat Neurosci. 2017 Feb;20(2):209-218. View Related Products by Target Other Targets

STOML3 inhibitor OB-1物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 628.5±55.0 °C at 760 mmHg
• 分子式: C₂₁H₁₇N₃O₆
• 分子量: 407.376
• 闪点: 333.9±31.5 °C
• 精确质量: 407.111725
• LogP: 5.15
• InChIKey: UJHGRDVYTTVJFD-UHFFFAOYSA-N
• SMILES: CCOC(=O)c1c(-c2ccccc2)oc2ccc(Oc3c([N+](=O)[O-])ncn3C)cc12
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.649

STOML3 inhibitor OB-1靶点实验

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实验名称：Small-molecule inhibitors of ST2 (IL1RL1) 来源：20881 靶标：interleukin-1 receptor-like 1 isoform [homo sapiens] External Id：ST2_IL33_Inhibitors_Primary_Screening_77700

实验名称：Inhibitors of CDC25B-CDK2/CyclinA interaction 来源：Center for Chemical Genomics, University of Michigan External Id：MScreen:TargetID_600

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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STOML3 inhibitor OB-1英文别名

• MFCD01462999
• 3-Benzofurancarboxylic acid, 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-, ethyl ester
• Ethyl 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-1-benzofuran-3-carboxylate