4'-[(3,5-dichloro-2-pyridinyl)oxy]-4-fluoro-2-oxospiro[1H-indole-3,1'-cyclohexane]-5-carboxamide

• 常用名: 4'-[(3,5-dichloro-2-pyridinyl)oxy]-4-fluoro-2-oxospiro[1H-indole-3,1'-cyclohexane]-5-carboxamide
• 英文名: 4'-[(3,5-dichloro-2-pyridinyl)oxy]-4-fluoro-2-oxospiro[1H-indole-3,1'-cyclohexane]-5-carboxamide
• CAS号: 3024591-38-3
• 分子量: 424.2
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₆Cl₂FN₃O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4'-[(3,5-dichloro-2-pyridinyl)oxy]-4-fluoro-2-oxospiro[1H-indole-3,1'-cyclohexane]-5-carboxamide

物理化学性质

• 分子式: C₁₉H₁₆Cl₂FN₃O₃
• 分子量: 424.2
• InChIKey: QHGIMBGZGUTRQK-UHFFFAOYSA-N
• SMILES: C1CC2(CCC1OC3=C(C=C(C=N3)Cl)Cl)C4=C(C=CC(=C4F)C(=O)N)NC2=O

靶点实验

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实验名称：Inhibition of DYRK1B (unknown origin) at 10 uM by Eurofins KINOMEscan assay relative ... 来源：ChEMBL 靶标：Dual specificity tyrosine-phosphorylation-regulated kinase 1B External Id：CHEMBL5586719

实验名称：Toxicity in male C57BL/6J mouse assessed as reduction in locomotion at 30 mg/kg, po m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5586720

实验名称：Toxicity in male C57BL/6J mouse assessed as reduction in grooming behavior at 30 mg/k... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5586721

实验名称：Toxicity in male C57BL/6J mouse assessed as reduction in temperature at 30 mg/kg, po ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5586722

实验名称：Invivo inhibition of IP6K1 in male C57BL/6J mouse assessed as decrease in IP7 level i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5586723

实验名称：Clearance in C57BL/6 mouse at 1 mg/kg, iv measured over 24 hrs by HPLC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5586724

实验名称：Half life in C57BL/6 mouse at 30 mg/kg, po measured over 24 hrs by HPLC-MS/MS analysi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5586725

实验名称：Inhibition of IP6K1 (unknown origin) using IP6 as substrate incubated for 30 mins in ... 来源：ChEMBL 靶标：Inositol hexakisphosphate kinase 1 External Id：CHEMBL5586702

实验名称：Efflux ratio of apparent permeability across basolateral to apical side over apical t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5586703

实验名称：Apparent permeability across apical to basolateral side in MDCK-MDR1 cells overexpres... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5586704

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