rel-(1r,4r)-4-(3-Chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide

• 常用名: rel-(1r,4r)-4-(3-Chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide
• 英文名: rel-(1r,4r)-4-(3-Chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide
• CAS号: 3038446-94-2
• 分子量: 893.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₃H₄₆ClFN₆O₁₀S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: rel-(1r,4r)-4-(3-Chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide

物理化学性质

• 分子式: C₄₃H₄₆ClFN₆O₁₀S
• 分子量: 893.4
• InChIKey: YDRHAKKUUAJFHB-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCOCCOCCOCCNC(=O)C4(CCC(CC4)OC5=C(C(=CC=C5)Cl)F)CC6=NC(=CC=C6)NC7=NC=CS7

靶点实验

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实验名称：PROTAC activity at AURKA/CRBN in human NGP cells assessed as AURKA degradation at 0.1... 来源：ChEMBL 靶标：Aurora kinase A External Id：CHEMBL5333199

实验名称：Growth inhibition of patient derived NB067 Neuroblastoma organoid assessed as reducti... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5333233

实验名称：PROTAC activity at AURKA/CRBN in human NGP cells assessed as AURKA degradation at 10 ... 来源：ChEMBL 靶标：Aurora kinase A External Id：CHEMBL5333234

实验名称：Growth inhibition of patient derived NB139 Neuroblastoma organoid assessed as reducti... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5333231

实验名称：Growth inhibition of patient derived 000GKX Neuroblastoma organoid assessed as reduct... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5333229

实验名称：Growth inhibition of patient derived NB059 Neuroblastoma organoid assessed as reducti... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5333227

实验名称：PROTAC activity at AURKA/CRBN in human NGP cells assessed as increase in H2AX phospho... 来源：ChEMBL 靶标：Aurora kinase A External Id：CHEMBL5333225

实验名称：Growth inhibition of patient derived NB059 Neuroblastoma organoid assessed as reducti... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5333226

实验名称：PROTAC activity at AURKA/CRBN in human NGP cells assessed as increase in pCHK1 level ... 来源：ChEMBL 靶标：Aurora kinase A External Id：CHEMBL5333223

实验名称：PROTAC activity at AURKA/CRBN in human NGP cells assessed as increase in pRPA32 level... 来源：ChEMBL 靶标：Aurora kinase A External Id：CHEMBL5333224

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