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Exo2

更新时间:2025-08-25 13:06:20

Exo2结构式
Exo2结构式
品牌特惠专场
常用名 Exo2 英文名 Exo2
CAS号 304684-77-3 分子量 354.42600
密度 N/A 沸点 N/A
分子式 C18H18N4O2S 熔点 N/A
MSDS 中文版 美版 闪点 N/A

 Exo2用途


Exo2是一种分泌抑制剂。Exo2干扰志贺毒素在内质体和跨高尔基体网络之间的运输。外显子2阻断从内质网(ER)分泌的货物出口并破坏高尔基体,但不影响TGN(跨高尔基网络)的形态。外显子2中可以刺激细胞中渗透性肾上腺髓质纤维的钙依赖性胞吐[1][2]。

 Exo2名称

英文名 Exo2

 Exo2生物活性

描述 Exo2是一种分泌抑制剂。Exo2干扰志贺毒素在内质体和跨高尔基体网络之间的运输。外显子2阻断从内质网(ER)分泌的货物出口并破坏高尔基体,但不影响TGN(跨高尔基网络)的形态。外显子2中可以刺激细胞中渗透性肾上腺髓质纤维的钙依赖性胞吐[1][2]。
相关类别
参考文献

[1]. Spooner RA, et al. The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Biochem J. 2008 Sep 15;414(3):471-84.

[2]. Morgan A, et al. Exo1 and Exo2 proteins stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells. Nature. 1992 Feb 27;355(6363):833-6.

 Exo2物理化学性质

分子式 C18H18N4O2S
分子量 354.42600
精确质量 354.11500
PSA 107.87000
LogP 3.80330

 Exo2安全信息

危险品运输编码 NONH for all modes of transport

 Exo2文献1

更多文献
The perilipin-2 (adipophilin) coat of cytosolic lipid droplets is regulated by an Arf1-dependent mechanism in HC11 mouse mammary epithelial cells.

Cell Biol. Int. 40 , 143-55, (2016)

The cytosolic lipid droplets (cLDs) store excess intracellular lipids, and perilipin-2 is believed to protect cLDs from degradation. Here, we investigated the role of the small G-protein Arf1 and the ...

 Exo2靶点实验

查看更多实验

实验名称:Selectivity index, ratio of IC50 for BALB/c mouse macrophages to IC50 for Leishmania ...
来源:ChEMBL
靶标:N/A
External Id:CHEMBL1104487
实验名称:Antileishmanial activity against Leishmania amazonensis MHOM/BR/76/LTB-012 amastigote...
来源:ChEMBL
靶标:Leishmania amazonensis
External Id:CHEMBL1104486
实验名称:Cytotoxicity against BALB/c mouse macrophages after 48 hrs by trypan blue dye exclusi...
来源:ChEMBL
靶标:N/A
External Id:CHEMBL1104485
实验名称:Cytotoxicity against human NCI-H460 cells
来源:ChEMBL
靶标:NCI-H460
External Id:CHEMBL1105367
实验名称:Cytotoxicity against BALB mouse 3T3 cells
来源:ChEMBL
靶标:NIH3T3
External Id:CHEMBL1104499
实验名称:Displacement of [3H]ZM241385 from human AA2AR expressed in HEK293T cells after 2 hrs ...
来源:ChEMBL
靶标:Adenosine receptor A2a
External Id:CHEMBL2073146
实验名称:Cytotoxicity against human K562 cells
来源:ChEMBL
靶标:K562
External Id:CHEMBL1105372
实验名称:Cytotoxicity against human HT-29 cells
来源:ChEMBL
靶标:HT-29
External Id:CHEMBL1105371
实验名称:Cytotoxicity against human M14 cells
来源:ChEMBL
靶标:M14
External Id:CHEMBL1105370
实验名称:Cytotoxicity against human MCF7 cells
来源:ChEMBL
靶标:MCF7
External Id:CHEMBL1105369
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