(3R)-3-[2-[[5-chloro-3-(difluoromethyl)pyrazol-1-yl]methyl]-7-methyl-4-oxopyrazolo[1,5-a]pyrazin-5-yl]butanenitrile

• 常用名: (3R)-3-[2-[[5-chloro-3-(difluoromethyl)pyrazol-1-yl]methyl]-7-methyl-4-oxopyrazolo[1,5-a]pyrazin-5-yl]butanenitrile
• 英文名: (3R)-3-[2-[[5-chloro-3-(difluoromethyl)pyrazol-1-yl]methyl]-7-methyl-4-oxopyrazolo[1,5-a]pyrazin-5-yl]butanenitrile
• CAS号: 3085030-47-0
• 分子量: 380.78
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₅ClF₂N₆O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (3R)-3-[2-[[5-chloro-3-(difluoromethyl)pyrazol-1-yl]methyl]-7-methyl-4-oxopyrazolo[1,5-a]pyrazin-5-yl]butanenitrile

物理化学性质

• 分子式: C₁₆H₁₅ClF₂N₆O
• 分子量: 380.78
• InChIKey: BEBDKSYNJJVZSO-SECBINFHSA-N
• SMILES: CC1=CN(C(=O)C2=CC(=NN12)CN3C(=CC(=N3)C(F)F)Cl)[C@H](C)CC#N

靶点实验

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实验名称：Thermal Shift Assay. Domain start/stop: M626-G740 来源：ChEMBL 靶标：Peregrin External Id：CHEMBL4650107

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Induction of LTP enhancement in Sprague-Dawley rat assessed as increase in LTP enhanc... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5145426

实验名称：Positive allosteric modulator activity at GluN1a/GluN2D (unknown origin) expressed in... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 2D External Id：CHEMBL5145422

实验名称：Selectivity index, ratio of EC50 for GluN1a/GluN2B (unknown origin) expressed in CHO ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5145423

实验名称：Selectivity index, ratio of EC50 for GluN1a/GluN2C (unknown origin) expressed in CHO ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5145424

实验名称：Selectivity index, ratio of EC50 for GluN1a/GluN2D (unknown origin) expressed in CHO ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5145425

实验名称：Ratio of drug concentration in brain to plasma at 3 mg/kg, po after 2 hr by LC-MS/MS ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5145418

实验名称：Positive allosteric modulator activity at GluN1a/GluN2B (unknown origin) expressed in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5145420

实验名称：Positive allosteric modulator activity at GluN1a/GluN2C (unknown origin) expressed in... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 2C External Id：CHEMBL5145421

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