2-(6-Chloro-3-((2,2-difluoro-2-(2-pyridinyl)ethyl)amino)-2-oxo-1(2H)-pyrazinyl)-N-((2-fluoro-6-pyridinyl)methyl)acetamide

• 常用名: 2-(6-Chloro-3-((2,2-difluoro-2-(2-pyridinyl)ethyl)amino)-2-oxo-1(2H)-pyrazinyl)-N-((2-fluoro-6-pyridinyl)methyl)acetamide
• 英文名: 2-(6-Chloro-3-((2,2-difluoro-2-(2-pyridinyl)ethyl)amino)-2-oxo-1(2H)-pyrazinyl)-N-((2-fluoro-6-pyridinyl)methyl)acetamide
• CAS号: 312904-60-2
• 分子量: 432.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₉F₃N₆O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 2-(6-Chloro-3-((2,2-difluoro-2-(2-pyridinyl)ethyl)amino)-2-oxo-1(2H)-pyrazinyl)-N-((2-fluoro-6-pyridinyl)methyl)acetamide

物理化学性质

• 分子式: C₂₀H₁₉F₃N₆O₂
• 分子量: 432.4
• InChIKey: JXHWVKOKYDAROD-UHFFFAOYSA-N
• SMILES: CC1=CN=C(C(=O)N1CC(=O)NCC2=C(C=CC=N2)F)NCC(C3=CC=CC=N3)(F)F

靶点实验

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实验名称：Concentration required to double the activated partial thromboplastin time (2x APTT) ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL696785

实验名称：Plasma half-life (1 mg/kg) dog after intravenous administration 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL642490

实验名称：Experimentally measured binding affinity data (Ki) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Ki for protein-ligand complexes

实验名称：Plasma half-life (10 mg/kg) in rat after intravenous administration 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL642491

实验名称：Inhibitory constant against human trypsin 来源：ChEMBL 靶标：Serine protease 1 External Id：CHEMBL815470

实验名称：Oral bioavailability in dog after administration of 1 mg/kg of compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL639650

实验名称：Plasma half-life (5 mg/kg) in rhesus monkey after intravenous administration 来源：ChEMBL 靶标：Macaca mulatta External Id：CHEMBL642494

实验名称：Plasma half-life in dog after peroral administration was evaluated 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL642495

实验名称：Oral bioavailability in rat (dose 10 mg/kg) 来源：ChEMBL 靶标：N/A External Id：CHEMBL639654

实验名称：Oral bioavailability in Rhesus monkey (dose 5 mg/kg) 来源：ChEMBL 靶标：N/A External Id：CHEMBL639655

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