4-(4-(5-巯基-1,3,4-恶二唑-2-基)苯基)硫糖甲酰肼

• 常用名: 4-(4-(5-巯基-1,3,4-恶二唑-2-基)苯基)硫糖甲酰肼
• 英文名: 4-(4-(5-Mercapto-1,3,4-oxadiazol-2-yl)phenyl) thioseMicarbazide
• CAS号: 317337-07-8
• 分子量: 267.33
• 密度: 1.5±0.1 g/cm3
• 沸点: 452.7±55.0 °C at 760 mmHg
• 分子式: C₉H₉N₅OS₂
• 熔点: N/A
• 闪点: 227.6±31.5 °C

用途

Stemazole 是一种促进干细胞存活的保护剂。Stemazole 具有人类胚胎干细胞(hESCs)的保护作用。Stemazole 增强单细胞的克隆扩增,降低细胞凋亡 (apoptosis)。Stemazole 用于干细胞在饥饿培养中存活的研究。

名称

• 中文名: 4-(4-(5-巯基-1,3,4-恶二唑-2-基)苯基)硫糖甲酰肼
• 英文名: stemazole

生物活性

• 描述: Stemazole 是一种促进干细胞存活的保护剂。Stemazole 具有人类胚胎干细胞(hESCs)的保护作用。Stemazole 增强单细胞的克隆扩增,降低细胞凋亡 (apoptosis)。Stemazole 用于干细胞在饥饿培养中存活的研究。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Sun Y, et al. Stemazole promotes survival and preserves stemness in human embryonic stem cells. FEBS J. 2018 Feb;285(3):531-541.

物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 452.7±55.0 °C at 760 mmHg
• 分子式: C₉H₉N₅OS₂
• 分子量: 267.33
• 闪点: 227.6±31.5 °C
• 精确质量: 267.024841
• PSA: 159.89000
• LogP: 2.02
• InChIKey: DSZWZHYEFYRNQI-UHFFFAOYSA-N
• SMILES: NNC(=S)Nc1ccc(-c2n[nH]c(=S)o2)cc1
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.762
• 储存条件: 室温

靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Induction of human HSC proliferation assessed as fold increase after 6 days by direct... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1799706

实验名称：Induction of human CSC proliferation after 4 days by luminescent cell viability assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1799705

实验名称：Induction of human HSC proliferation under serum free condition at 5 to 40 uM by cell... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1799626

实验名称：Solubility of the compound in DMSO 来源：ChEMBL 靶标：N/A External Id：CHEMBL1799625

实验名称：Cytotoxicity against human HSC assessed as morphological changes 13.8 to 40.2 uM up t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1799702

实验名称：Induction of human HSC proliferation assessed as population doubling time at 41.6 uM ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1799701

实验名称：Induction of human PSC proliferation after 4 days by luminescent cell viability assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1799704

实验名称：Cytotoxicity against human HSC assessed as axonal growth or adipose drop appearance 1... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1799703

实验名称：High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS1303

共13条，当前第1页，共2页

1

2

英文别名

• 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl) semicarbazide
• hydrazino-4-(5-sulfanyl-1,3,4-oxadiazol-2-yl)anilinomethanethione
• 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)thiosemicarbazide
• 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl) thiosemicarbazide
• N-[4-(5-Thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]hydrazinecarbothioamide