41F5

• 常用名: 41F5
• 英文名: 41F5
• CAS号: 327077-97-4
• 分子量: 350.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₂N₂OS
• 熔点: N/A
• 闪点: N/A

41F5用途

41F5为抗离心剂。41F5对组织浆酵母具有高活性(MIC50为0.4-0.8μM)。41F5对组织浆酵母具有抑菌活性,50%的抑制浓度(IC50)为0.87μM,并且相对于宿主细胞对酵母具有最大的选择性(至少62倍)。

41F5名称

• 英文名: 41F5

41F5生物活性

• 描述: 41F5为抗离心剂。41F5对组织浆酵母具有高活性(MIC50为0.4-0.8μM)。41F5对组织浆酵母具有抑菌活性,50%的抑制浓度(IC50)为0.87μM,并且相对于宿主细胞对酵母具有最大的选择性(至少62倍)。
• 参考文献: 1. Khalil A, Edwards JA, Rappleye CA, Tjarks W. Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans. Bioorg Med Chem. 2015 Feb 1;23(3):532-47. doi: 10.1016/j.bmc.2014.12.006. Epub 2014 Dec 10. PubMed PMID: 25543205; PubMed Central PMCID: PMC4302056.

41F5物理化学性质

• 分子式: C₂₁H₂₂N₂OS
• 分子量: 350.48
• InChIKey: WJAMFZVSJYMDDT-UHFFFAOYSA-N
• SMILES: O=C(Nc1ncc(Cc2cccc3ccccc23)s1)C1CCCCC1

41F5靶点实验

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实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Antifungal activity against Histoplasma capsulatum G217B ATCC 26032 at pH 5 measured ... 来源：ChEMBL 靶标：Histoplasma capsulatum External Id：CHEMBL4222864

实验名称：Ratio of aqueous solubility at pH 5 to aqueous solubility at pH 7 来源：ChEMBL 靶标：N/A External Id：CHEMBL4222863

实验名称：Antifungal activity against wild type fluconazole-sensitive Cryptococcus neoformans s... 来源：ChEMBL 靶标：Cryptococcus neoformans External Id：CHEMBL4222865

实验名称：Antifungal activity against RFP expressing Histoplasma capsulatum infected in LacZ-ex... 来源：ChEMBL 靶标：Histoplasma capsulatum External Id：CHEMBL4222860

实验名称：Antifungal activity against fluconazole-resistant Cryptococcus neoformans serotype A ... 来源：ChEMBL 靶标：Cryptococcus neoformans External Id：CHEMBL4222859

实验名称：Aqueous solubility of the compound at pH 7 来源：ChEMBL 靶标：N/A External Id：CHEMBL4222862

实验名称：Aqueous solubility of the compound at pH 5 来源：ChEMBL 靶标：N/A External Id：CHEMBL4222861

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