还原氟哌啶醇

更新时间：2024-01-03 19:55:27

还原氟哌啶醇结构式	常用名	还原氟哌啶醇	英文名	Haloperidol Metabolite II
	CAS号	34104-67-1	分子量	377.88000
	密度	1.247g/cm3	沸点	531.2ºC at 760 mmHg
	分子式	C₂₁H₂₅ClFNO₂	熔点	125-127°C
	MSDS	美版	闪点	275.1ºC

还原氟哌啶醇用途

Reduced haloperidol is an active metabolite of haloperidol formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake.

中文名	还原氟哌啶醇
英文名	Reduced Haloperidol
英文别名	更多

密度	1.247g/cm3
沸点	531.2ºC at 760 mmHg
熔点	125-127°C
分子式	C₂₁H₂₅ClFNO₂
分子量	377.88000
闪点	275.1ºC
精确质量	377.15600
PSA	43.70000
LogP	4.21420
外观性状	white
折射率	1.589
储存条件	Refrigerator
水溶解性	DMSO: soluble10mg/mL

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
WGK德国	3
海关编码	2933399090

氟哌啶醇

52-86-8

~88%

还原氟哌啶醇

34104-67-1

文献：Yang, Shi-Bing; Major, Felix; Tietze, Lutz F.; Rupnik, Marjan Journal of Pharmacology and Experimental Therapeutics, 2005 , vol. 315, # 1 p. 352 - 362

4-[4-(4-chlorop...

34104-51-3

还原氟哌啶醇

34104-67-1

文献：US3936468 A1, ;

还原氟哌啶醇上游产品 2
CAS号52-86-8 氟哌啶醇 CAS号34104-51-3 4-[4-(4-chlorop...
还原氟哌啶醇下游产品 1
CAS号52-86-8 氟哌啶醇

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.

Psychopharmacology 205 , 21-33, (2009)

We evaluated the effects of haloperidol and its metabolites on capsaicin-induced mechanical hypersensitivity (allodynia) and on nociceptive pain induced by punctate mechanical stimuli in mice.Subcutan...

Determination of haloperidol and reduced haloperidol in human serum by liquid chromatography after fluorescence labeling based on the Suzuki coupling reaction.

Anal. Bioanal. Chem 386(3) , 719-24, (2006)

A simultaneous method for the determination of haloperidol (HP) and its metabolite, reduced haloperidol (RHP), in human serum was developed by means of high-performance liquid chromatography (HPLC) wi...

Plasma reduced haloperidol/haloperidol ratios in schizophrenic patients treated with high dosages of haloperidol.

Eur. Neuropsychopharmacol. 4(2) , 119-26, (1994)

Plasma haloperidol (HL) and reduced haloperidol (RH) levels were measured in 60 schizophrenic patients treated with high to very high HL doses of 40-200 mg/day. Plasma samples were obtained at steady-...

Haloperidol metabolite II