2-(6-Chloro-3-{[2,2-difluoro-2-(1-oxido-2-pyridinyl)ethyl]amino}-2-oxo-1(2H)-pyrazinyl)-N-[(2-fluorophenyl)methyl]acetamide

• 常用名: 2-(6-Chloro-3-{[2,2-difluoro-2-(1-oxido-2-pyridinyl)ethyl]amino}-2-oxo-1(2H)-pyrazinyl)-N-[(2-fluorophenyl)methyl]acetamide
• 英文名: 2-(6-Chloro-3-{[2,2-difluoro-2-(1-oxido-2-pyridinyl)ethyl]amino}-2-oxo-1(2H)-pyrazinyl)-N-[(2-fluorophenyl)methyl]acetamide
• CAS号: 342815-51-4
• 分子量: 467.8
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₇ClF₃N₅O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 2-(6-Chloro-3-{[2,2-difluoro-2-(1-oxido-2-pyridinyl)ethyl]amino}-2-oxo-1(2H)-pyrazinyl)-N-[(2-fluorophenyl)methyl]acetamide

物理化学性质

• 分子式: C₂₀H₁₇ClF₃N₅O₃
• 分子量: 467.8
• InChIKey: ZIGSBBKEPNQXRG-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)CNC(=O)CN2C(=CN=C(C2=O)NCC(C3=CC=CC=[N+]3[O-])(F)F)Cl)F

靶点实验

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实验名称：Inhibitory activity against human thrombin 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL879191

实验名称：Experimentally measured binding affinity data (Ki) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Ki for protein-ligand complexes

实验名称：t1/2 in dog 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL624478

实验名称：Inhibitory constant against thrombin 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL884569

实验名称：Vd (10 mg/kg) was determined in rat (in vivo) 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL635584

实验名称：Vd (5 mg/kg) was determined in rhesus (in vivo) 来源：ChEMBL 靶标：Macaca mulatta External Id：CHEMBL635585

实验名称：Concentration required to double the activated partial thromboplastin time(APPT) afte... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL774102

实验名称：Concentration required to double the activated partial thromboplastin time (aPPT) in ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL702833

实验名称：Oral bioavailability (10 mg/kg) was determined in rat 来源：ChEMBL 靶标：N/A External Id：CHEMBL629400

实验名称：Plasma level after intravenous administration in rat model of FeCl3-induced carotid t... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL626270

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