XR-11576 HCl

更新时间：2026-04-26 12:05:09

XR-11576 HCl用途

XR-11576 HCl 是一种新型口服活性拓扑异构酶I 和II 双重抑制剂,具有抗肿瘤活性。

英文名	XR-11576 HCl

描述	XR-11576 HCl 是一种新型口服活性拓扑异构酶I 和II 双重抑制剂,具有抗肿瘤活性。
体外研究	XR-11576对过表达耐多药蛋白(MRP)的耐多药人非小细胞肺癌癌症细胞系COR-L23(COR-L23/R)具有抑制作用(IC50=0.0121µM)。[1]
参考文献	1. Vicker N, et al. Novel angular benzophenazines: dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents. J Med Chem. 2002;45(3):721-739.

分子式	C₂₃H₂₅ClN₄O₂
分子量	424.92
InChIKey	ACAXGYADTLFREX-CQSZACIVSA-N
SMILES	COc1cccc2c1ccc1nc3cccc(C(=O)NC(C)CN(C)C)c3nc12

实验名称：pharmacokinetics in female BALB/c mice measured as Vss after 50 mg/kg iv administrati...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL725676

实验名称：Rf is the resistance factor and is the ratio of the IC50 on the resistant cell line o...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL639900

实验名称：Rf is the resistance factor and is the ratio of the IC50 on the resistant cell line o...
来源：ChEMBL
靶标：NCI-H69
External Id：CHEMBL639901

实验名称：Inhibitory activity against murine P388 leukemia (P388) cells.
来源：ChEMBL
靶标：P388
External Id：CHEMBL756788

实验名称：Cytotoxicity measured using the drug resistant, P-glycoprotein (Pgp) expressing human...
来源：ChEMBL
靶标：NCI-H69
External Id：CHEMBL683165

实验名称：pharmacokinetics in female BALB/c mice measured as Kel after 20 mg/kg iv administrati...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL725218

实验名称：Inhibitory activity against drug resistant H69/LX4 line overexpressing P-glycoprotein
来源：ChEMBL
靶标：NCI-H69
External Id：CHEMBL683167

实验名称：pharmacokinetics in female BALB/c mice measured as Kel after 50 mg/kg Preoral adminis...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL725220

实验名称：pharmacokinetics in female BALB/c mice measured as Kel after 50 mg/kg iv administrati...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL725219

实验名称：pharmacokinetics in female BALB/c mice measured as AUC after 50 mg/kg iv administrati...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL714621

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